Next departures for Syracuse to Charlotte on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Next departures for Syracuse to Charlotte on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
CheapestFastest
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Next departures for Syracuse to Charlotte on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Syracuse (Regional Transportation Center)
Charlotte Bus Station
No tags
Last refresh of the prices: Last Thursday at 1:19 AM EST.
Compare 2 ways to go from Syracuse to Charlotte
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Charlotte. The journey takes about 19 hours 24 minutes and with fares starting at just $183, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Trailways is a network of over 70 bus companies that focus on providing quality bus rides at affordable prices all over the US since 1936. Among the most famous affiliates are Trailways of New York, Pine Hill Trailways, Adirondack Trailways and Burlington Trailways. Trailways buses have WiFi, power outlets, bathrooms, air conditioning, overhead lighting, and reclinable seats with footrests. You can find two different types of Trailway fares: saver and flexible. Saver tickets are non-refundable, while flexible tickets are fully reimbursed up to one hour before travel time. If you're traveling with them, don't forget to print your boarding pass and show a valid photo ID to board the bus.
Based on 1126 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the ticket access and the cleanliness but often complained with the wifi. Adirondack Trailways ticket prices on this trip start at $351
Frequently asked questions about traveling from Syracuse, US to Charlotte, NC by bus
How much does a bus ticket from Syracuse to Charlotte cost?
The bus ticket price from Syracuse to Charlotte starts at $90. The best way to find cheap bus tickets from Syracuse to Charlotte is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Syracuse to Charlotte?
The average travel time between Syracuse and Charlotte is around 21h 20m, although the fastest bus will take about 18h 25m. This is the time it takes to travel the 596 miles that separates the two cities.
How many daily bus connections are there between Syracuse and Charlotte?
The number of buses from Syracuse to Charlotte can differ depending on the day of the week. On average, there are 9 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to Charlotte by comparing and selecting the bus that fits you travel style and budget on Busbud.
Which bus companies travel from Syracuse to Charlotte?
When taking the bus from Syracuse to Charlotte, you can travel comfortably and safely with FlixBus, Greyhound, New York Trailways.
What are the departure and arrival stations when taking the bus from Syracuse to Charlotte?
Buses traveling between Syracuse and Charlotte leave from Regional Transportation Center or Syracuse Airport and arrive at Tornado & El Expreso Bus Company, Charlotte Douglas International Airport, Charlotte Greyhound Bus Station.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$172
11/23
$184
Today
$134
11/25
$306
11/26
$126
11/27
$133
11/28
$137
11/29
$221
The cheapest trip from Syracuse, US to Charlotte, NC was searched and found on Nov 26, 2025 with a price of $126
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Charlotte, NC, as early as possible.
You can expect to pay from $126 to $306 for a bus ticket from Syracuse, US to Charlotte, NC based on the last 2 days. You can expect to find the cheapest price for the trip at $126 which is on 2025-11-26.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Syracuse, US to Charlotte, NC?
The bus is the cheapest travel choice for this destination
The cheapest trip from Syracuse, US to Charlotte, NC was searched and found on Nov 26, 2025 with a price of $126
The bus is the cheapest travel choice for this destination
