Bus Tickets from Rome to Karlsruhe

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Previously seen trips

One passenger / one way

  • Departure time: September 2 at
    Departure city: Rome
    Departure location: Rome Tiburtina Bus Station
    Arrival time: September 3 at
    Destination city: Karlsruhe
    Destination location: Südseite Hauptbahnhof
    Operated by: MarinoBusMarinoBus
    Vehicle: BusDuration:
  • Departure time: August 20 at
    Departure city: Rome
    Departure location: Rome Tiburtina Bus Station
    Arrival time: August 21 at
    Destination city: Karlsruhe
    Destination location: Südseite Hauptbahnhof
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 20 at
    Departure city: Rome
    Departure location: Rome Anagnina
    Arrival time: August 21 at
    Destination city: Karlsruhe
    Destination location: Südseite Hauptbahnhof
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 20 at
    Departure city: Rome
    Departure location: Aeroporto Ciampino Airport (CIA)
    Arrival time: August 21 at
    Destination city: Karlsruhe
    Destination location: Südseite Hauptbahnhof
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 20 at
    Departure city: Rome
    Departure location: Rome Tiburtina Bus Station
    Arrival time: August 21 at
    Destination city: Karlsruhe
    Destination location: Südseite Hauptbahnhof
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Bus Rome to Karlsruhe: Trip Overview

Average ticket price$147
Average bus trip duration19h 15m
Number of daily buses4
Earliest bus departure5:15am
Distance527 miles (850 km)
Latest bus departure11:50pm

Rome to Karlsruhe Bus

With Busbud, comparing and booking tickets for a bus from Rome to Karlsruhe is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Rome to Karlsruhe from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Rome to Karlsruhe, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Rome - Karlsruhe

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/20
$100
08/21
No data
Today
No data
08/23
No data
08/24
No data
08/25
No data
08/26
$147
08/27
No data
busbud logoThe cheapest trip from Rome to Karlsruhe was searched and found on Aug 20, 2025 with a price of $100

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Karlsruhe, as early as possible.

You can expect to pay from $100 to $232 for a bus ticket from Rome to Karlsruhe based on the last 2 days. You can expect to find the cheapest price for the trip at $147 which is on 2025-08-26.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Rome to Karlsruhe.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Rome to Karlsruhe, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Rome to Karlsruhe that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Rome to Karlsruhe.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Rome by bus?

Bus from Karlsruhe to Rome

You can also go to Karlsruhe by train

Train from Rome to Karlsruhe

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