Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Buses La Serena | Av. Balmaceda | Cheapest | ||||
| Bus | Terminal de Buses La Serena | Av. Balmaceda | Fastest | ||||
| Bus | Terminal de Buses La Serena | Av. Balmaceda | No tags | ||||
 | Bus | La Serena (Bus terminal La Serena) | Calama (Terminale de buses Granaderos) | No tags | ||||
| Bus | Terminal de Buses La Serena | Av. Balmaceda | No tags | ||||
| Bus | La Serena (Bus terminal La Serena) | Calama (Terminale de buses Granaderos) | No tags | ||||
| Bus | Terminal de Buses La Serena | Av. Balmaceda | No tags | ||||
| Bus | La Serena (Bus terminal La Serena) | Calama (Terminale de buses Granaderos) | No tags |
Last refresh of the prices: Last Tuesday at 3:27 PM -03.
Get from La Serena to Calama
The journey takes about 15 hours 50 minutes, and with fares starting at just $42, it presents an excellent value for a comfortable ride.
Compare bus companies
Where are the popular stops in La Serena and Calama?
Frequently asked questions about travelling from La Serena, CL to Calama by bus
How far is La Serena from Calama?
The distance between La Serena and Calama is approximately 861 km (534 miles).
What are the departure and arrival locations for buses traveling from La Serena to Calama?
Buses departing from Terminal de Buses La Serena in La Serena will take you to Av. Balmaceda in Calama.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Serena, CL to Calama was searched and found on Nov 17, 2025 with a price of $40To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Calama, as early as possible.
You can expect to pay from $40 to $69 for a bus ticket from La Serena, CL to Calama based on the last 2 days. You can expect to find the cheapest price for the trip at $40 which is on 2025-11-17.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top travelled bus routes
People from around the world trust Busbud
Popular Buses Connecting La Serena
Buses Leaving from La Serena
- Bus from La Serena to Coquimbo
- Bus La Serena - Santiago
- La Serena - Ovalle
- Bus from La Serena to Antofagasta
- Bus La Serena - Vallenar
- La Serena - Vicuña
- Bus from La Serena to Linares
- Bus La Serena - Concon
- La Serena - Caldera
- Bus from La Serena to Talca
- Bus La Serena - Placilla
- La Serena - Valparaiso
- Bus from La Serena to Copiapo
- Bus La Serena - Curacavi
- La Serena - Calama
Buses Going to La Serena
- Bus from Santiago to La Serena
- Bus Ovalle - La Serena
- Calama - La Serena
- Bus from Copiapo to La Serena
- Bus Temuco - La Serena
- Valparaiso - La Serena
- Bus from Vicuña to La Serena
- Bus Concon - La Serena
- Caldera - La Serena
- Bus from Antofagasta to La Serena
- Bus Diego de Almagro - La Serena
- Los Vilos - La Serena
- Bus from Pullalli to La Serena
- Bus Vallenar - La Serena
- Baquedano - La Serena
Popular Buses Connecting Calama
Buses Leaving from Calama
- Bus from Calama to Iquique
- Bus Calama - La Serena
- Calama - Antofagasta
- Bus from Calama to Sierra Gorda
- Bus Calama - Copiapo
- Calama - Coquimbo
- Bus from Calama to Concon
- Bus Calama - Pullalli
- Calama - Vallenar
- Bus from Calama to Pozo Almonte
- Bus Calama - Quillota
- Calama - Taltal
- Bus from Calama to Pichidangui
- Bus Calama - La Calera
Buses Going to Calama
- Bus from Copiapo to Calama
- Bus Iquique - Calama
- Sierra Gorda - Calama
- Bus from Uyuni to Calama
- Bus Coquimbo - Calama
- Salta - Calama
- Bus from Ovalle to Calama
- Bus Vallenar - Calama
- Antofagasta - Calama
- Bus from Pullalli to Calama
- Bus La Serena - Calama
- Quillota - Calama
- Bus from Baquedano to Calama
- Bus Taltal - Calama
- La Calera - Calama
Popular routes in this country
- Bus from Castro to Ancud
- Bus Puerto Varas - Castro
- Santiago - Pucon
- Bus from Santiago to Valparaiso
- Bus Calama - Santiago
- Puerto Montt - Pucon
- Bus from Santiago to Vina del Mar
- Bus Puerto Natales - Estancia Pudeto
- Calama - Arica Province
- Bus from Ancud to Puerto Montt
- Bus Temuco - Pucon
- Arica Province - Calama
- Bus from Valdivia to Santiago
- Bus Santiago - Antofagasta
- Pucon - Santiago