Bus Tickets from Santiago, CL to Antofagasta

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TodayAug 7
from US$33
TomorrowAug 8
from US$32
SatAug 9
from US$41
SunAug 10
from US$41
MonAug 11
from US$25
TueAug 12
from US$25
WedAug 13
from US$25
ThuAug 14
from US$35

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 8 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: August 9 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: August 9 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: August 9 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: August 9 at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja
    Arrival time: August 9 at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 11:16 PM -04.

Prices and availability are subject to change.

Accepted payments

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Bus Santiago, CL to Antofagasta: Trip Overview

Average Ticket PriceUS$47
Average Bus Trip Duration18h 40m
Number of daily buses34
Earliest bus departure7:35am
Distance1094 km
Latest bus departure11:45pm

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - Antofagasta

  1. What is the travel distance from Santiago to Antofagasta?

    The distance between Santiago and Antofagasta is around 1091 km (677 miles).

  2. What are the departure and arrival locations for buses traveling from Santiago to Antofagasta?

    Buses traveling this route start their trip at San Borja, in Santiago, and end it at Terminal Antofagasta, in Antofagasta.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-05
US$30
08-06
US$30
Today
US$30
08-08
US$30
08-09
US$37
08-10
US$38
08-11
US$23
08-12
US$23
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on Aug 12, 2025 with a price of US$23

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta, as early as possible.

You can expect to pay from US$23 to US$63 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$23 which is on 2025-08-12.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to Antofagasta will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Santiago, CL to Antofagasta

Why choose Busbud?

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