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- This trip is recommended because it is the: Cheapest
- This trip is recommended because it is the: Fastest
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Bus Santiago, CL to Antofagasta: Trip Overview
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Santiago to Antofagasta Bus
With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.
Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Santiago and Antofagasta?
Frequently asked questions on the trip Santiago, CL - Antofagasta
How far is Antofagasta from Santiago by coach?
The distance between Santiago and Antofagasta by coach is approximately 677 miles (1091 km).
Is there a way to reach Antofagasta from Santiago without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta as early as possible.
You can expect to pay from US$23 to US$63 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$23, which is on 2025-08-12.
Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Antofagasta will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Top travelled bus routes
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Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Temuco
- Coach Santiago - La Serena
- Bus Santiago - Talca
- Santiago - Valdivia
- Bus from Santiago to Chillan
- Coach Santiago - Rancagua
- Bus Santiago - Santa Cruz
- Santiago - Puerto Varas
- Bus from Santiago to Pichilemu
- Coach Santiago - San Pedro de la Paz
- Bus Santiago - Casablanca
- Santiago - Castro
- Bus from Santiago to Iquique
- Coach Santiago - Frutillar
- Bus Santiago - Villarrica
Buses Going to Santiago
- Bus from Victoria to Santiago
- Coach Concepción - Santiago
- Bus Castro - Santiago
- San Felipe - Santiago
- Bus from Antofagasta to Santiago
- Coach Quintero - Santiago
- Bus San Pedro de la Paz - Santiago
- Puerto Varas - Santiago
- Bus from Penco to Santiago
- Coach Copiapo - Santiago
- Bus Osorno Province - Santiago
- Santa Cruz - Santiago
- Bus from Vina del Mar to Santiago
- Coach San Antonio - Santiago
- Bus Temuco - Santiago
Popular Buses Connecting Antofagasta
Buses Leaving from Antofagasta
- Bus from Antofagasta to Santiago
- Coach Antofagasta - Sierra Gorda
- Bus Antofagasta - Coquimbo
- Antofagasta - Tocopilla
- Bus from Antofagasta to Iquique
- Coach Antofagasta - Vallenar
- Bus Antofagasta - Calama
- Antofagasta - Ovalle
- Bus from Antofagasta to Arica Province
- Coach Antofagasta - Copiapo
- Bus Antofagasta - Taltal
- Antofagasta - Baquedano
- Bus from Antofagasta to La Serena
- Coach Antofagasta - Alto Hospicio
- Bus Antofagasta - Caldera
Buses Going to Antofagasta
- Bus from Iquique to Antofagasta
- Coach La Serena - Antofagasta
- Bus Tocopilla - Antofagasta
- Sierra Gorda - Antofagasta
- Bus from Taltal to Antofagasta
- Coach Calama - Antofagasta
- Bus Copiapo - Antofagasta
- Arica Province - Antofagasta
- Bus from Caldera to Antofagasta
- Coach Coquimbo - Antofagasta
- Bus Vallenar - Antofagasta
- Ovalle - Antofagasta
- Bus from Alto Hospicio to Antofagasta
- Coach La Calera - Antofagasta
- Bus Los Vilos - Antofagasta
Popular routes in this country
- Bus from Santiago to Valparaiso
- Coach Santiago - Pucon
- Bus Pucon - Santiago
- Puerto Montt - Pucon
- Bus from Calama to Santiago
- Coach Santiago - Antofagasta
- Bus Pucon - Puerto Montt
- Puerto Montt - Santiago
- Bus from Puerto Natales to Estancia Pudeto
- Coach Puerto Varas - Pucon
- Bus Santiago - Vina del Mar
- Pucon - Puerto Varas
- Bus from La Serena to Calama
- Coach Valdivia - Santiago
- Bus La Serena - Santiago
Popular airport transfers
Popular international trips
- Travel in Chile
- Bus to Santiago, CL
- Bus to Antofagasta
- Santiago, CL to Antofagasta Buses