Find coaches from Santiago, CL to Antofagasta

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Today7 Aug
from US$33
Tomorrow8 Aug
from US$32
Sat9 Aug
from US$41
Sun10 Aug
from US$41
Mon11 Aug
from US$25
Tue12 Aug
from US$25
Wed13 Aug
from US$25
Thu14 Aug
from US$35

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 8 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 9 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 8 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 9 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 9 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 9 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja
    Arrival time: 9 August at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

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Bus Santiago, CL to Antofagasta: Trip Overview

Average ticket priceUS$47
Average bus trip duration18h 40m
Number of daily buses34
Earliest bus departure07:35
Distance679 miles
Latest bus departure23:45

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - Antofagasta

  1. How far is Antofagasta from Santiago by coach?

    The distance between Santiago and Antofagasta by coach is approximately 677 miles (1091 km).

  2. Is there a way to reach Antofagasta from Santiago without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/08
US$30
06/08
US$30
Today
US$30
08/08
US$30
09/08
US$37
10/08
US$38
11/08
US$23
12/08
US$23
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on 12 Aug 2025 with a price of US$23

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta as early as possible.

You can expect to pay from US$23 to US$63 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$23, which is on 2025-08-12.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Antofagasta will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Santiago, CL to Antofagasta

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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