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Bus Santiago, CL to Antofagasta: Trip Overview
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Santiago to Antofagasta Bus
With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.
Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Santiago and Antofagasta?
Frequently asked questions on the trip Santiago, CL - Antofagasta
How much does a bus ticket from Santiago to Antofagasta cost?
The bus ticket price from Santiago to Antofagasta starts at US$24. The best way to find cheap bus tickets from Santiago to Antofagasta is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Santiago to Antofagasta?
The average travel time between Santiago and Antofagasta is around 18h 40m, although the fastest bus will take about 17h 15m. This is the time it takes to travel the 677 miles that separates the two cities.
How many daily bus connections are there between Santiago and Antofagasta?
The number of buses from Santiago to Antofagasta can differ depending on the day of the week. On average, there are 34 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santiago to Antofagasta by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Santiago to Antofagasta?
When taking the bus from Santiago to Antofagasta, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, Pullman San Andres.
What are the departure and arrival stations when taking the bus from Santiago to Antofagasta?
Buses travelling between Santiago and Antofagasta leave from San Borja or Terminal Sur and arrive at Av. Pedro Aguirre Cerda, 253, Terminal Antofagasta, Terminal Flota Barrios.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta as early as possible.
You can expect to pay from US$23 to US$53 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$23, which is on 2025-08-13.
Usually PlussChile, Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Antofagasta will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Top travelled bus routes
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Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Temuco
- Coach Santiago - La Serena
- Bus Santiago - Valdivia
- Santiago - Chillan
- Bus from Santiago to Talca
- Coach Santiago - Rancagua
- Bus Santiago - Santa Cruz
- Santiago - Puerto Varas
- Bus from Santiago to Pichilemu
- Coach Santiago - San Pedro de la Paz
- Bus Santiago - Casablanca
- Santiago - Castro
- Bus from Santiago to Iquique
- Coach Santiago - Frutillar
- Bus Santiago - Villarrica
Buses Going to Santiago
- Bus from Victoria to Santiago
- Coach Concepción - Santiago
- Bus Castro - Santiago
- San Felipe - Santiago
- Bus from Vina del Mar to Santiago
- Coach Antofagasta - Santiago
- Bus San Pedro de la Paz - Santiago
- Puerto Varas - Santiago
- Bus from Penco to Santiago
- Coach Copiapo - Santiago
- Bus Osorno Province - Santiago
- Santa Cruz - Santiago
- Bus from Temuco to Santiago
- Coach San Antonio - Santiago
- Bus Caldera - Santiago
Popular Buses Connecting Antofagasta
Buses Leaving from Antofagasta
- Bus from Antofagasta to Santiago
- Coach Antofagasta - Sierra Gorda
- Bus Antofagasta - Coquimbo
- Antofagasta - Tocopilla
- Bus from Antofagasta to Iquique
- Coach Antofagasta - Vallenar
- Bus Antofagasta - Calama
- Antofagasta - Ovalle
- Bus from Antofagasta to Arica Province
- Coach Antofagasta - Copiapo
- Bus Antofagasta - Taltal
- Antofagasta - Baquedano
- Bus from Antofagasta to La Serena
- Coach Antofagasta - Caldera
- Bus Antofagasta - Alto Hospicio
Buses Going to Antofagasta
- Bus from Iquique to Antofagasta
- Coach La Serena - Antofagasta
- Bus Tocopilla - Antofagasta
- Sierra Gorda - Antofagasta
- Bus from Taltal to Antofagasta
- Coach Calama - Antofagasta
- Bus Copiapo - Antofagasta
- Arica Province - Antofagasta
- Bus from Caldera to Antofagasta
- Coach Coquimbo - Antofagasta
- Bus Vallenar - Antofagasta
- Ovalle - Antofagasta
- Bus from La Calera to Antofagasta
- Coach Alto Hospicio - Antofagasta
- Bus Pozo Almonte - Antofagasta
Popular routes in this country
- Bus from Santiago to Valparaiso
- Coach Santiago - Pucon
- Bus Pucon - Santiago
- Puerto Montt - Pucon
- Bus from Calama to Santiago
- Coach Santiago - Antofagasta
- Bus Pucon - Puerto Montt
- Puerto Montt - Santiago
- Bus from Puerto Natales to Estancia Pudeto
- Coach Puerto Varas - Pucon
- Bus Santiago - Vina del Mar
- Pucon - Puerto Varas
- Bus from La Serena to Calama
- Coach Valdivia - Santiago
- Bus La Serena - Santiago
Popular airport transfers
Popular international trips
- Travel in Chile
- Bus to Santiago, CL
- Bus to Antofagasta
- Santiago, CL to Antofagasta Buses