Find coaches from Santiago, CL to Antofagasta

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Today11 Aug
from US$35
Tomorrow12 Aug
from US$33
Wed13 Aug
from US$25
Thu14 Aug
from US$35
Fri15 Aug
from US$25
Sat16 Aug
from US$25
Sun17 Aug
from US$25
Mon18 Aug
from US$25

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 12 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 13 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 13 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 13 August at
    Destination city: Antofagasta
    Destination location: Terminal Antofagasta
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja
    Arrival time: 13 August at
    Destination city: Antofagasta
    Destination location: 5791 Avenida Iquique
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: 12 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 13 August at
    Destination city: Antofagasta
    Destination location: Terminal Carlos Oviedo Cavada
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:

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Bus Santiago, CL to Antofagasta: Trip Overview

Average ticket priceUS$47
Average bus trip duration18h 40m
Number of daily buses34
Earliest bus departure07:35
Distance679 miles
Latest bus departure23:45

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - Antofagasta

  1. How much does a bus ticket from Santiago to Antofagasta cost?

    The bus ticket price from Santiago to Antofagasta starts at US$24. The best way to find cheap bus tickets from Santiago to Antofagasta is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Santiago to Antofagasta?

    The average travel time between Santiago and Antofagasta is around 18h 40m, although the fastest bus will take about 17h 15m. This is the time it takes to travel the 677 miles that separates the two cities.

  3. How many daily bus connections are there between Santiago and Antofagasta?

    The number of buses from Santiago to Antofagasta can differ depending on the day of the week. On average, there are 34 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santiago to Antofagasta by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Santiago to Antofagasta?

    When taking the bus from Santiago to Antofagasta, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, Pullman San Andres.

  5. What are the departure and arrival stations when taking the bus from Santiago to Antofagasta?

    Buses travelling between Santiago and Antofagasta leave from San Borja or Terminal Sur and arrive at Av. Pedro Aguirre Cerda, 253, Terminal Antofagasta, Terminal Flota Barrios.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/08
US$33
10/08
US$33
Today
US$33
12/08
US$31
13/08
US$23
14/08
US$33
15/08
US$23
16/08
US$23
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on 13 Aug 2025 with a price of US$23

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta as early as possible.

You can expect to pay from US$23 to US$53 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at US$23, which is on 2025-08-13.

Usually PlussChile, Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Antofagasta will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Santiago, CL to Antofagasta

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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