Find coaches from Antofagasta to La Serena, CL

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Today7 Aug
from US$21
Tomorrow8 Aug
from US$35
Sat9 Aug
from US$21
Sun10 Aug
from US$21
Mon11 Aug
from US$35
Tue12 Aug
from US$21
Wed13 Aug
from US$21
Thu14 Aug
from US$21

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 8 August at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 9 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 8 August at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 8 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 8 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: 9 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus Elité + Pluss Chile
    Cikbus Elité + Pluss Chile
    Vehicle: BusDuration:
  • Departure time: 8 August at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: 9 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:

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Bus Antofagasta to La Serena, CL: Trip Overview

Average ticket priceUS$41
Average bus trip duration11h 30m
Number of daily buses25
Earliest bus departure00:15
Distance438 miles
Latest bus departure23:50

Antofagasta to La Serena Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Antofagasta to La Serena.

We make sure you can find a bus service from Antofagasta to La Serena from the most reliable bus companies operating this trip.

Discover how much the bus trip from Antofagasta to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Antofagasta - La Serena, CL

  1. How much does a bus ticket from Antofagasta to La Serena cost?

    The bus ticket price from Antofagasta to La Serena starts at US$21. The best way to find cheap bus tickets from Antofagasta to La Serena is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Antofagasta to La Serena?

    The average travel time between Antofagasta and La Serena is around 11h 30m, although the fastest bus will take about 9h. This is the time it takes to travel the 437 miles that separates the two cities.

  3. How many daily bus connections are there between Antofagasta and La Serena?

    The number of buses from Antofagasta to La Serena can differ depending on the day of the week. On average, there are 25 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Antofagasta to La Serena by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Antofagasta to La Serena?

    When taking the bus from Antofagasta to La Serena, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, Pullman San Andres.

  5. What are the departure and arrival stations when taking the bus from Antofagasta to La Serena?

    Buses travelling between Antofagasta and La Serena leave from Av. Pedro Aguirre Cerda, 253 or Terminal Antofagasta and arrive at Terminal de Buses La Serena, Rotonda La Serena.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/08
US$26
06/08
US$27
Today
US$19
08/08
US$32
09/08
US$19
10/08
US$19
11/08
US$32
12/08
US$19
busbud logoThe cheapest trip from Antofagasta to La Serena, CL was searched and found on 9 Aug 2025 with a price of US$19

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to La Serena, CL as early as possible.

You can expect to pay from US$19 to US$52 for a bus ticket from Antofagasta to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$19, which is on 2025-08-09.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Antofagasta to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Antofagasta to La Serena, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Antofagasta to La Serena will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to La Serena, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Antofagasta by bus?

Bus from Antofagasta to La Serena, CL

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Popular Buses Connecting Antofagasta

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Popular Buses Connecting La Serena

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