Bus Tickets from Santiago, CL to Santa Cruz, CL

Find affordable bus tickets from Santiago, CL to Santa Cruz, CL with flexible options. Book your trip now

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TodayAug 7
from US$7
TomorrowAug 8
from US$7
SatAug 9
from US$7
SunAug 10
from US$7
MonAug 11
from US$7
TueAug 12
from US$7
WedAug 13
from US$7
ThuAug 14
from US$7

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: August 8 at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: August 8 at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: August 8 at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses TranSantinBuses TranSantin
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: August 8 at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:
  • Departure time: August 8 at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: August 8 at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 9:21 PM -04.

Prices and availability are subject to change.

Accepted payments

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Bus Santiago, CL to Santa Cruz, CL: Trip Overview

Average Ticket PriceUS$8
Average Bus Trip Duration3h
Number of daily buses25
Earliest bus departure6:10am
Distance146 km
Latest bus departure8:59pm

Santiago to Santa Cruz Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Santa Cruz is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Santa Cruz from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Santiago to Santa Cruz, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Santiago, CL - Santa Cruz, CL

  1. What is the travel distance from Santiago to Santa Cruz?

    It's about 153 km (95 miles) from Santiago to Santa Cruz.

  2. What are the departure and arrival locations for buses traveling from Santiago to Santa Cruz?

    Buses traveling this route start their trip at Terminal Sur, in Santiago, and end it at Terminal Santa Cruz, in Santa Cruz.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-05
US$7
08-06
US$7
Today
US$7
08-08
US$7
08-09
US$7
08-10
US$7
08-11
US$7
08-12
US$7
busbud logoThe cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on Aug 8, 2025 with a price of US$7

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL, as early as possible.

You can expect to pay from US$7 to US$10 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$7 which is on 2025-08-08.

Usually Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Santa Cruz.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Santa Cruz, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santiago to Santa Cruz that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to Santa Cruz while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Santiago, CL by bus?

Bus from Santiago, CL to Santa Cruz, CL

Why choose Busbud?

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