Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | Cheapest | |||||
Greyhound Lines, Inc. + FlixBus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | Fastest | |||||
 | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Pittsburgh Intermodal Station | 1116 Woodruff Rd | No tags |
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Compare 2 ways to go from Pittsburgh to Greenville.
Busbud recommends taking the bus from Pittsburgh to GreenvilleAmong the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 18 hours 10 minutes and with fares starting at just $74, it presents an excellent value for a comfortable ride.
Bus Pittsburgh to Greenville, SC: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Pittsburgh to Greenville Bus
With Busbud, comparing and booking tickets for a bus from Pittsburgh to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Pittsburgh to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Pittsburgh, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Pittsburgh and Greenville?
Frequently asked questions for your trip Pittsburgh - Greenville, SC
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Greenville, SC was searched and found on Sep 12, 2025 with a price of $77To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Greenville, SC, as early as possible.
You can expect to pay from $77 to $86 for a bus ticket from Pittsburgh to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $77 which is on 2025-09-12.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Pittsburgh to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Pittsburgh to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Pittsburgh to Greenville.
Tune out to the fine sounds of your best music playlist on your bus trip from Pittsburgh to Greenville while indulging in miles on end of beautiful scenic views.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Pittsburgh to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Pittsburgh
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Popular Buses Connecting Greenville
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Buses Going to Greenville
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Popular routes in this country
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