How much is the bus ticket from Greenville to Chicago?

The cheapest bus tickets from Greenville to Chicago start from $100. The average price for this route is around $171. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Greenville to Chicago?

The average bus trip duration from Greenville to Chicago is 21h 30m, covering a distance of 556 miles (896 km). The quickest bus can get you there in 20h 55m and is operated by Greyhound .

Which bus companies service the Greenville to Chicago route?

Several major bus companies operate on this route with 13 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Greenville to Chicago?

The earliest bus departs from Greenville to Chicago at 1:20pm. And the latest bus departs at 10:00pm.

What are the CO₂ emissions for the bus trip from Greenville to Chicago?

A bus trip from Greenville to Chicago generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Greenville to Chicago?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 11504 reviews.

Which bus company has the best Wi-Fi from Greenville to Chicago?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Greenville to Chicago?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Greenville to Chicago?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to Chicago from $115 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Chicago on December 10
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound	Bus	7:45pm	1116 Woodruff Rd	20h 40m	3:25pm	Downtown Greyhound Station	No tags
Greyhound + FlixBus	Bus	7:45pm	1116 Woodruff Rd	20h 40m	3:25pm	Downtown Greyhound Station	No tags
FlixBus + Greyhound	Bus	7:45pm	1116 Woodruff Rd	23h 50m	6:35pm	Chicago 95Th & Dan Ryan	No tags
Greyhound + FlixBus	Bus	7:45pm	1116 Woodruff Rd	23h 50m	6:35pm	Chicago 95Th & Dan Ryan	No tags
FlixBus + Greyhound	Bus	7:45pm	1116 Woodruff Rd	1d 13h	8:05am	537-517 W. Jackson Blvd	No tags

Compare 2 ways to go from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just $100, it presents an excellent value for a comfortable ride.

13bus per day

21h 30mAverage Duration

556 milesDistance

22kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$100 - $477	Average Duration21h 30m	CO₂ emissions 22kg CO₂e
Train	Average Price$177 - $2,129	Average Duration1d 7h	CO₂ emissions 82kg CO₂e

Where are the popular stops in Greenville and Chicago?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

FlixBus

3.5/511,565 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,422 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Greenville, SC to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Greenville to Chicago?
The cheapest bus tickets from Greenville to Chicago start from $100. The average price for this route is around $171. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Chicago?
The average bus trip duration from Greenville to Chicago is 21h 30m, covering a distance of 556 miles (896 km). The quickest bus can get you there in 20h 55m and is operated by Greyhound.
Which bus companies service the Greenville to Chicago route?
Several major bus companies operate on this route with 13 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Greenville to Chicago?
The earliest bus departs from Greenville to Chicago at 1:20pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Chicago?
A bus trip from Greenville to Chicago generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Greenville to Chicago?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11504 reviews.
Which bus company has the best Wi-Fi from Greenville to Chicago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Greenville to Chicago?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/07

$150

12/08

$121

Today

$165

12/10

$122

12/11

No data

12/12

$126

12/13

No data

12/14

$115

The cheapest trip from Greenville, SC to Chicago was searched and found on Dec 14, 2025 with a price of $115

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.

You can expect to pay from $115 to $189 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $115 which is on 2025-12-14.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.