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One passenger / one way
- This trip is recommended because it is: CheapestDeparture time: August 8 atDeparture city: GreenvilleDeparture location: 1116 Woodruff RdArrival time: August 9 atDestination city: ChicagoDestination location: Chicago 95Th & Dan RyanOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is: Fastest
- Departure time: August 8 atDeparture city: GreenvilleDeparture location: 1116 Woodruff RdArrival time: August 9 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: FlixBusVehicle: BusDuration:
- Departure time: August 8 atDeparture city: GreenvilleDeparture location: 1116 Woodruff RdArrival time: August 9 atDestination city: ChicagoDestination location: 537-517 W. Jackson BlvdOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
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Compare 2 ways to go from Greenville to Chicago.
Busbud recommends taking the bus from Greenville to ChicagoAmong the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 21 hours 25 minutes and with fares starting at just $83, it presents an excellent value for a comfortable ride.
Bus Greenville, SC to Chicago: Trip Overview
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Greenville to Chicago Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Chicago.
We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Chicago.
Whether it is cheap bus tickets or more luxurious buses going to Chicago from Greenville, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Greenville and Chicago?
Frequently asked questions for your trip Greenville, SC - Chicago
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Chicago was searched and found on Aug 12, 2025 with a price of $101To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.
You can expect to pay from $101 to $197 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $101 which is on 2025-08-12.
Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Greenville to Chicago.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Chicago.
Make a music playlist for your bus ride from Greenville to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Greenville, SC to Chicago?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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