Next departures for Pittsburgh to Chicago on November 17
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Cheapest
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
Fastest
Bus
Pittsburgh Intermodal Station
537-517 W. Jackson Blvd
No tags
Next departures for Pittsburgh to Chicago on November 18
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Pittsburgh to Chicago on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Pittsburgh to Chicago on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Next departures for Pittsburgh to Chicago on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Pittsburgh to Chicago on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Pittsburgh to Chicago on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Next departures for Pittsburgh to Chicago on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Cheapest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
Fastest
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Bus
Pittsburgh Intermodal Station
Downtown Greyhound Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Pittsburgh Intermodal Station
Chicago 95Th & Dan Ryan
No tags
Last refresh of the prices: Today at 7:22 AM EST.
Compare 2 ways to go from Pittsburgh to Chicago
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 9 hours 46 minutes and with fares starting at just $52, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Pittsburgh Chicago recent customer reviews
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Pittsburgh to Chicago by bus
What is the distance between Pittsburgh and Chicago?
Pittsburgh and Chicago are 410 miles (661 km) apart.
What are the departure and arrival stations when taking the bus from Pittsburgh to Chicago?
If you're headed to Chicago from Pittsburgh, chances are that your bus will depart from Intermodal Station and arrive at Downtown Greyhound Station. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Lake Michigan, Navy Pier, Museum of Science and Industry, Lincoln Park Conservatory and Cloud Gate.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/15
$82
11/16
$82
Today
$89
11/18
$78
11/19
$81
11/20
$79
11/21
$87
11/22
$89
The cheapest trip from Pittsburgh to Chicago was searched and found on Nov 18, 2025 with a price of $78
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Chicago, as early as possible.
You can expect to pay from $78 to $208 for a bus ticket from Pittsburgh to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $78 which is on 2025-11-18.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.