Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Jefferson Lines + Jefferson Lines | Bus | 314 Jay St., La Crosse | Chicago (Bus Station) | CheapestFastest | ||||
 | Bus | 314 Jay St., La Crosse | Chicago (Bus Station) | No tags | ||||
| Bus | La Crosse (U of WI) | Chicago (Bus Station) | No tags | ||||
Jefferson Lines + Jefferson Lines | Bus | La Crosse (U of WI) | Chicago (Bus Station) | No tags |
Last refresh of the prices: Yesterday at 9:36 AM CST.
Compare 2 ways to go from La Crosse to Chicago
Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just $34, it presents an excellent value for a comfortable ride.
Compare bus companies
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Frequently asked questions about traveling from La Crosse, WI to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Crosse to Chicago?
The cheapest bus tickets from La Crosse to Chicago start from $155. The average price for this route is around $184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Chicago?
The average bus trip duration from La Crosse to Chicago is 16h 20m, covering a distance of 226 miles (364 km). The quickest bus can get you there in 16h 20m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Chicago route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from La Crosse to Chicago?
The earliest bus departs from La Crosse to Chicago at 1:10pm. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from La Crosse to Chicago?
A bus trip from La Crosse to Chicago generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Chicago was searched and found on Mar 3, 2026 with a price of $179To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago, as early as possible.
You can expect to pay from $179 to $179 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $179 which is on 2026-03-06.
Top traveled bus routes
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