Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Crosse MTU Transit Center | Minneapolis | Cheapest | ||||
| Bus | La Crosse MTU Transit Center | Minneapolis (U of MN - Huron Blvd) | Fastest | ||||
Jefferson Lines + Jefferson Lines | Bus | 632 17th Street North | Minneapolis (Mall of America) | No tags | ||||
| Bus | La Crosse MTU Transit Center | MSP Airport T1 (Minneapolis International Airport) | No tags | ||||
Jefferson Lines + Jefferson Lines | Bus | La Crosse MTU Transit Center | MSP Airport T1 (Minneapolis International Airport) | No tags |
Last refresh of the prices: Last Saturday at 1:37 PM CST.
Get from La Crosse to Minneapolis
The journey takes about 6 hours 5 minutes and with fares starting at just $30, it presents an excellent value for a comfortable ride.
Compare bus companies
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Jefferson Lines La Crosse Minneapolis recent customer reviews
Comfy trip. On time. Friendly and competent driver.
Melora P.
Frequently asked questions about traveling from La Crosse, WI to Minneapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Crosse to Minneapolis?
The cheapest bus tickets from La Crosse to Minneapolis start from $30. The average price for this route is around $34. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Minneapolis?
The average bus trip duration from La Crosse to Minneapolis is 6h 5m, covering a distance of 123 miles (198 km). The quickest bus can get you there in 4h 5m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Minneapolis route?
Several major train operators operate on this route with 14 trains available per day.
What is the earliest and latest departure time for the bus from La Crosse to Minneapolis?
The earliest bus departs from La Crosse to Minneapolis at 12:25pm. And the latest bus departs at 12:50pm.
What are the CO₂ emissions for the bus trip from La Crosse to Minneapolis?
A bus trip from La Crosse to Minneapolis generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Minneapolis was searched and found on Dec 4, 2025 with a price of $29To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Minneapolis, as early as possible.
You can expect to pay from $29 to $83 for a bus ticket from La Crosse, WI to Minneapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $29 which is on 2025-12-04.
