How much is the bus ticket from La Crosse to Milwaukee?

The cheapest bus tickets from La Crosse to Milwaukee start from $41. The average price for this route is around $46. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from La Crosse to Milwaukee?

The average bus trip duration from La Crosse to Milwaukee is 4h 40m, covering a distance of 175 miles (282 km). The quickest bus can get you there in 3h 45m and is operated by Jefferson Lines .

Which bus companies service the La Crosse to Milwaukee route?

Several major bus companies operate on this route with 3 buses available per day, including services from Megabus , Jefferson Lines .

What is the earliest and latest departure time for the bus from La Crosse to Milwaukee?

The earliest bus departs from La Crosse to Milwaukee at 2:30pm. And the latest bus departs at 4:10pm.

What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?

A bus trip from La Crosse to Milwaukee generates an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from La Crosse to Milwaukee?

According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines , with an average rating of 3.9 out of 5 stars based on 759 reviews.

Which bus company has the best Wi-Fi from La Crosse to Milwaukee?

Based on reviews on Busbud, the bus company Jefferson Lines has the best Wi-Fi rating with a score of 3.1.

Which bus company has the most timely service from La Crosse to Milwaukee?

According to Busbud traveller reviews, the most timely bus company on this route is Jefferson Lines , with a punctuality rating of 3.8 out of 5 stars.

Which bus company has the cleanest buses from La Crosse to Milwaukee?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus , with a cleanliness rating of 4.3 out of 5 stars.

Bus La Crosse to Milwaukee from $39 | Refundable Tickets

Next bus departures

Next departures for La Crosse to Milwaukee on December 3
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 4
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 5
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 6
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on December 7
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Next departures for La Crosse to Milwaukee on December 8
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Next departures for La Crosse to Milwaukee on December 9
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Last refresh of the prices: Yesterday at 2:16 PM CST.

Compare 2 ways to go from La Crosse to Milwaukee

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Milwaukee. The journey takes about 3 hours 36 minutes and with fares starting at just $27, it presents an excellent value for a comfortable ride.

4train per day

3h 36mAverage Duration

178 milesDistance

26kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$41 - $57	Average Duration4h 40m	CO₂ emissions 7kg CO₂e
Train	Average Price$27 - $128	Average Duration3h 36m	CO₂ emissions 26kg CO₂e

Compare bus companies

Megabus

3.5/5413 reviews

Staff4.1

Timeliness3.7

Cleanliness4.3

Wifi2.4

Traveling with Megabus from La Crosse to Milwaukee is an affordable and reliable way to reach your destination. The company provides amenities like comfortable seats and free Wi-Fi (on most buses), ensuring a comfortable journey. Discover an easy and budget-friendly travel option to Milwaukee with Megabus. Tickets start at just $46, with an average price of around $51, making it an accessible choice for travelers.

Jefferson Lines

4/5759 reviews

Staff4

Timeliness3.8

Cleanliness4

Wifi3.2

Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.

Jefferson Lines La Crosse Milwaukee recent customer reviews

confusing instructions to where the bus would pick me up, made me miss my bus. awful return exchange policy, so i cant do anything about it

Kaitlyn S.

January 30, 2022

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from La Crosse, WI to Milwaukee by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from La Crosse to Milwaukee?
The cheapest bus tickets from La Crosse to Milwaukee start from $41. The average price for this route is around $46. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Milwaukee?
The average bus trip duration from La Crosse to Milwaukee is 4h 40m, covering a distance of 175 miles (282 km). The quickest bus can get you there in 3h 45m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Milwaukee route?
Several major bus companies operate on this route with 3 buses available per day, including services from Megabus, Jefferson Lines.
What is the earliest and latest departure time for the bus from La Crosse to Milwaukee?
The earliest bus departs from La Crosse to Milwaukee at 2:30pm. And the latest bus departs at 4:10pm.
What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?
A bus trip from La Crosse to Milwaukee generates an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from La Crosse to Milwaukee?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 759 reviews.
Which bus company has the best Wi-Fi from La Crosse to Milwaukee?
Based on reviews on Busbud, the bus company Jefferson Lines has the best Wi-Fi rating with a score of 3.1.
Which bus company has the most timely service from La Crosse to Milwaukee?
According to Busbud traveller reviews, the most timely bus company on this route is Jefferson Lines, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from La Crosse to Milwaukee?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus, with a cleanliness rating of 4.3 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/30

$43

12/01

$43

Today

$43

12/03

$43

12/04

$43

12/05

$39

12/06

$39

12/07

$43

The cheapest trip from La Crosse, WI to Milwaukee was searched and found on Dec 5, 2025 with a price of $39

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Milwaukee, as early as possible.

You can expect to pay from $39 to $54 for a bus ticket from La Crosse, WI to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at $39 which is on 2025-12-05.

Usually Megabus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.