Find coaches from La Crosse, WI to Chicago

Previously seen journeys

Next departures from La Crosse to Chicago on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
    		632 17th Street North
    		Chicago (Bus Station)No tags
    Jefferson Lines
      		La Crosse MTU Transit Center
      		Chicago (Bus Station)No tags
      Jefferson Lines
        		632 17th Street North
        		Chicago (Bus Station)No tags
        Jefferson Lines
          		La Crosse MTU Transit Center
          		Chicago (Bus Station)No tags
          Jefferson Lines
            		632 17th Street North
            		Chicago (Bus Station)No tags

            Accepted payments

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            • China Union Pay
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            • Google Pay

            Compare 2 ways to travel from La Crosse to Chicago

            We recommend taking the train

            Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just US$34, it presents an excellent value for a comfortable ride.

            3train per day
            5h 8mAverage duration
            366 kmDistance
            33kgCO₂ emissions
            Bus
            		Average priceUS$184 - US$203Average duration17h 15m
            9kg CO₂e
            Train
            		Average priceUS$34 - US$266Average duration5h 8m
            33kg CO₂e

            Bus La Crosse, WI to Chicago: Trip Overview

            Average ticket priceUS$184
            Average bus trip duration17h 15m
            Number of daily buses2
            Earliest bus departure12:25
            Distance365 km
            Latest bus departure12:50

            La Crosse to Chicago Bus

            Busbud helps you find a bus from La Crosse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make sure you can find a bus service from La Crosse to Chicago from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to Chicago from La Crosse, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip La Crosse, WI - Chicago

            1. How much does a bus ticket from La Crosse to Chicago cost?

              The bus ticket price from La Crosse to Chicago starts at US$184. The best way to find cheap bus tickets from La Crosse to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from La Crosse to Chicago?

              The average travel time between La Crosse and Chicago is around 17h 15m, although the fastest bus will take about 17h 15m. This is the time it takes to travel the 367 km that separates the two cities.

            3. How many daily bus connections are there between La Crosse and Chicago?

              The number of buses from La Crosse to Chicago can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from La Crosse to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from La Crosse to Chicago?

              When taking the bus from La Crosse to Chicago, you can travel comfortably and safely with Jefferson Lines.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            29/10
            No data
            30/10
            US$179
            Today
            US$179
            01/11
            US$179
            02/11
            No data
            03/11
            No data
            04/11
            No data
            05/11
            No data
            busbud logoThe cheapest trip from La Crosse, WI to Chicago was searched and found on 30 Oct 2025 with a price of US$179

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago as early as possible.

            You can expect to pay from US$179 to US$179 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$179, which is on 2025-11-01.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Crosse and Chicago!

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from La Crosse to Chicago, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Crosse to Chicago.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from La Crosse to Chicago.

            Did you know?

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            You can also go to Chicago by train

            Train from La Crosse, WI to Chicago

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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