Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Jefferson Lines + Jefferson Lines | Bus | 314 Jay St., La Crosse | Chicago (Bus Station) | CheapestFastest | ||||
 | Bus | 314 Jay St., La Crosse | Chicago (Bus Station) | No tags | ||||
| Bus | La Crosse (U of WI) | Chicago (Bus Station) | No tags | ||||
Jefferson Lines + Jefferson Lines | Bus | La Crosse (U of WI) | Chicago (Bus Station) | No tags |
Last refresh of the prices: Yesterday at 7:09 PM CST.
Compare 2 ways to go from La Crosse to Chicago
Among the sustainable travel choices, the Train stands out as a good way to reach Chicago. The journey takes about 5 hours 8 minutes, and with fares starting at just $47, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 766 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Jefferson Lines ticket prices on this trip start at $258
Frequently asked questions about travelling from La Crosse, WI to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Crosse to Chicago?
The cheapest bus tickets from La Crosse to Chicago start from $218. The average price for this route is around $258. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Crosse to Chicago?
The average bus travel time from La Crosse to Chicago is 16h 20m, covering a distance of 364 km. The quickest bus can get you there in 16h 20m and is operated by Jefferson Lines.
Which bus companies service the La Crosse to Chicago route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from La Crosse to Chicago?
The earliest bus departs from La Crosse to Chicago at 1:10pm. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from La Crosse to Chicago?
A bus trip from La Crosse to Chicago generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Crosse, WI to Chicago was searched and found on Mar 3, 2026 with a price of $251To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago, as early as possible.
You can expect to pay from $251 to $251 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $251 which is on 2026-03-06.
