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- This trip is recommended because it is the: Cheapest + FastestDeparture time: August 8 atDeparture city: KnoxvilleDeparture location: Knoxville Bus StationArrival time: August 9 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
Last refresh of the prices: Last Friday at 3:29 PM EDT.
Prices and availability are subject to change.
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Bus Knoxville, TN to Greenville, SC: Trip Overview
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Based on 87162 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$56
Knoxville to Greenville Bus
With Busbud, comparing and booking tickets for a bus from Knoxville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Knoxville, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Knoxville and Greenville?
Frequently asked questions on the trip Knoxville, TN - Greenville, SC
What is the travel distance from Knoxville to Greenville?
The distance covered from Knoxville to Greenville is 186 km (115 miles).
What are the departure and arrival locations for buses traveling from Knoxville to Greenville?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Guadalajara Supermarket Bus Stop, in Greenville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Aug 8, 2025 with a price of US$49To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.
You can expect to pay from US$49 to US$97 for a bus ticket from Knoxville, TN to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$49 which is on 2025-08-08.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Knoxville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Greenville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Greenville.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top travelled bus routes
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Popular Buses Connecting Knoxville
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Popular Buses Connecting Greenville
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Buses Going to Greenville
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