Bus Tickets from Knoxville, TN to Greenville, SC

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TodayAug 11
TomorrowAug 12
from US$98
WedAug 13
from US$89
ThuAug 14
from US$74
FriAug 15
from US$91
SatAug 16
from US$98
SunAug 17
MonAug 18
from US$83

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 12 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 13 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Saturday at 11:26 AM EDT.

Prices and availability are subject to change.

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Bus Knoxville, TN to Greenville, SC: Trip Overview

Average Ticket PriceUS$86
Average Bus Trip Duration12h 5m
Number of daily buses1
Earliest bus departure7:25pm
Distance193 km

Knoxville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Knoxville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Knoxville, TN - Greenville, SC

  1. What is the travel distance from Knoxville to Greenville?

    The distance covered from Knoxville to Greenville is 186 km (115 miles).

  2. What are the departure and arrival locations for buses traveling from Knoxville to Greenville?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-09
No data
08-10
US$113
Today
US$145
08-12
US$90
08-13
US$81
08-14
US$67
08-15
US$83
08-16
US$90
busbud logoThe cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Aug 14, 2025 with a price of US$67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.

You can expect to pay from US$67 to US$145 for a bus ticket from Knoxville, TN to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$67 which is on 2025-08-14.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Greenville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Knoxville, TN by bus?

Bus from Knoxville, TN to Greenville, SC

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