Bus Tickets from Knoxville, TN to Indianapolis

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TodayAug 6
TomorrowAug 7
from US$83
FriAug 8
from US$79
SatAug 9
from US$74
SunAug 10
from US$72
MonAug 11
TueAug 12
WedAug 13

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 7 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 8 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 7 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 7 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 7 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 1:58 AM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Knoxville, TN to Indianapolis: Trip Overview

Average Ticket PriceUS$96
Average Bus Trip Duration14h 10m
Number of daily buses3
Earliest bus departure6:15pm
Distance464 km
Latest bus departure7:25pm

Knoxville to Indianapolis Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Indianapolis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Knoxville to Indianapolis will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Knoxville to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Knoxville, TN - Indianapolis

  1. How far is Knoxville from Indianapolis?

    The distance between Knoxville and Indianapolis is around 468 km (290 miles).

  2. What are the departure and arrival locations for buses traveling from Knoxville to Indianapolis?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-04
US$70
08-05
US$89
Today
US$91
08-07
US$76
08-08
US$72
08-09
US$67
08-10
US$74
08-11
No data
busbud logoThe cheapest trip from Knoxville, TN to Indianapolis was searched and found on Aug 9, 2025 with a price of US$67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis, as early as possible.

You can expect to pay from US$67 to US$121 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$67 which is on 2025-08-09.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to Indianapolis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Knoxville to Indianapolis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Indianapolis that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Knoxville to Indianapolis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Knoxville, TN by bus?

Bus from Knoxville, TN to Indianapolis

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