Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Knoxville Bus Station | 537-517 W. Jackson Blvd | Fastest | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Yesterday at 10:45 AM EST.
Get from Knoxville to Chicago
The journey takes about 20 hours, and with fares starting at just $111, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Chicago?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Frequently asked questions about travelling from Knoxville, TN to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Chicago?
The cheapest bus tickets from Knoxville to Chicago start from $111. The average price for this route is around $232. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Chicago?
The average bus travel time from Knoxville to Chicago is 20h, covering a distance of 730 km. The quickest bus can get you there in 14h 40m and is operated by Greyhound.
Which bus companies service the Knoxville to Chicago route?
Several major bus companies operate on this route with 7 buses available per day.
What are the earliest and latest departure times for the bus from Knoxville to Chicago?
The earliest bus departs from Knoxville to Chicago at 6:10pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Knoxville to Chicago?
A bus trip from Knoxville to Chicago generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Chicago was searched and found on Dec 11, 2025 with a price of $195To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Chicago, as early as possible.
You can expect to pay from $195 to $465 for a bus ticket from Knoxville, TN to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $195 which is on 2025-12-11.
