Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Knoxville Bus Station | 537-517 W. Jackson Blvd | Fastest | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Knoxville Bus Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Today at 10:46 AM EST.
Get from Knoxville to Chicago
The journey takes about 20 hours and with fares starting at just $78, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Chicago?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Knoxville Chicago recent customer reviews
the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. I wrote to the support service, I wanted to return the ticket due to the bus being late and fly by plane, but they answered me with automatic messages. the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. and I also didn’t like that they woke me up and kicked me off the bus at every stop
Artur T.
We were waylaid for an incredible 7 hours between Knoxville and Nashville because of an extremely suspect technical issue regarding the brightness of headlights. During this time a customer, understandably dissatisfied with the ride and the information given to them, expressed this to the driver whereupon the driver called the police on the passenger who was escorted off the bus by cops. Following our arrival into Knoxville we were again delayed when, due to understaffing, we were unable to get our redirected tickets in time. The actual ticketing staff at the Nashville terminal is the only reason the employees get 2 stars. He deserves a raise and probably a better job. Finally, after everything was sorted and we made our way into Chicago, our luggage went untransfered in Indianapolis and we had to return to get it the next day. This was a nightmarish ordeal and I will, from here on out, be spending my money on alternative methods of transportation.
Willem D.
It took us to get to home 24hrs instead 12 hrs with additional cost of $230 due to delay and no bus available at connections.
Nareshkumar P.
Frequently asked questions about traveling from Knoxville, TN to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Chicago?
The cheapest bus tickets from Knoxville to Chicago start from $78. The average price for this route is around $164. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Chicago?
The average bus trip duration from Knoxville to Chicago is 20h, covering a distance of 453 miles (730 km). The quickest bus can get you there in 14h 40m and is operated by Greyhound.
Which bus companies service the Knoxville to Chicago route?
Several major train operators operate on this route with 7 trains available per day.
What is the earliest and latest departure time for the bus from Knoxville to Chicago?
The earliest bus departs from Knoxville to Chicago at 6:10pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Knoxville to Chicago?
A bus trip from Knoxville to Chicago generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Chicago was searched and found on Dec 4, 2025 with a price of $116To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Chicago, as early as possible.
You can expect to pay from $116 to $328 for a bus ticket from Knoxville, TN to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $137 which is on 2025-12-11.
