Bus Tickets from Greenville, SC to Knoxville, TN

Previously seen trips

Next departures for Greenville to Knoxville on October 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
1116 Woodruff Rd
Knoxville Bus StationNo tags
Greyhound + FlixBus
1116 Woodruff Rd
Knoxville Bus StationNo tags
FlixBus + Greyhound
1116 Woodruff Rd
Knoxville Bus StationNo tags
FlixBus + Greyhound
1116 Woodruff Rd
Knoxville Bus StationNo tags
FlixBus + Greyhound
1116 Woodruff Rd
Knoxville Bus StationNo tags

Accepted payments

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  • China Union Pay
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Bus Greenville, SC to Knoxville, TN: Trip Overview

Average Ticket PriceUS$54
Average Bus Trip Duration7h 5m
Number of daily buses1
Earliest bus departure2:45pm
Distance193 km

Greenville to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Knoxville.

Bus service from Greenville to Knoxville will be provided by the most trusted bus companies.

Discover how much the bus trip from Greenville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Greenville, SC - Knoxville, TN

  1. How far is Greenville from Knoxville?

    The distance between Greenville and Knoxville is approximately 186 km (115 miles).

  2. What are the departure and arrival locations for buses traveling from Greenville to Knoxville?

    Buses departing from Guadalajara Supermarket Bus Stop in Greenville will take you to 100 Kirkwood St in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-01
US$71
10-02
No data
Today
US$46
10-04
US$42
10-05
No data
10-06
No data
10-07
No data
10-08
No data
busbud logoThe cheapest trip from Greenville, SC to Knoxville, TN was searched and found on Oct 4, 2025 with a price of US$42

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Knoxville, TN, as early as possible.

You can expect to pay from US$42 to US$71 for a bus ticket from Greenville, SC to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$42 which is on 2025-10-04.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Greenville to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Knoxville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Greenville to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Greenville, SC by bus?

Bus from Knoxville, TN to Greenville, SC

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