Bus Tickets from Orlando to Greenville, SC

Find affordable bus tickets from Orlando to Greenville, SC with flexible options. Book your trip now

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TodayAug 11
TomorrowAug 12
from US$72
WedAug 13
from US$72
ThuAug 14
FriAug 15
from US$92
SatAug 16
SunAug 17
from US$92
MonAug 18

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: August 13 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: August 13 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: August 12 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: August 12 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 12 at
    Departure city: Orlando
    Departure location: Orlando Bus Station
    Arrival time: August 13 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 10:11 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Orlando to Greenville

Bus
Average PriceUS$71 - US$223Average Duration12h
18kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$129 - US$1,405Average Duration1d 10h
65kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Orlando to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 12 hours, and with fares starting at just US$71, it presents an excellent value for a comfortable ride.

5bus per day
12hAverage Duration
US$71Cheapest ticket
18kgCO₂ emissions

Bus Orlando to Greenville, SC: Trip Overview

Average Ticket PriceUS$94
Average Bus Trip Duration12h
Number of daily buses5
Earliest bus departure5:15am
Distance704 km
Latest bus departure10:55pm

Orlando to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Orlando to Greenville.

We make sure you can find a bus service from Orlando to Greenville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Orlando to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Orlando - Greenville, SC

  1. What is the distance between Orlando and Greenville?

    Orlando and Greenville are 710 km (440 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Orlando to Greenville?

    Buses departing from Orlando Bus Station in Orlando will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-09
No data
08-10
US$129
Today
US$69
08-12
US$70
08-13
US$64
08-14
US$66
08-15
US$88
08-16
No data
busbud logoThe cheapest trip from Orlando to Greenville, SC was searched and found on Aug 13, 2025 with a price of US$64

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Greenville, SC, as early as possible.

You can expect to pay from US$64 to US$132 for a bus ticket from Orlando to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$64 which is on 2025-08-13.

Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Orlando to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Orlando to Greenville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Orlando to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Orlando to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Orlando to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Orlando by bus?

Bus from Orlando to Greenville, SC

You can also go to Greenville, SC by train

Train from Orlando to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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