What is the travel distance from Tampa to Florence?

Tampa and Florence are 464 miles (747 km) apart.

What are the departure and arrival stations when taking the bus from Tampa to Florence?

The majority of buses traveling from Tampa to Florence start their journey at Tampa 13th Avenue Bus Stop (McDonald's) and wind up at Florence Bus Station. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Palazzo Vecchio, Santa Maria Novella, Basilica di San Lorenzo, Leonardo Da Vinci Museum and Tuscan Wine Tour.

Bus Tampa to Florence from $65 | Refundable Tickets

Previously seen trips

Next departures for Tampa to Florence on November 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	9:30am	Tampa Bus Station	14h 29m	11:59pm	Florence, SC	No tags
Greyhound + FlixBus	Bus	10:25pm	University of South Florida	17h 40m	4:05pm	Bus station	No tags
Greyhound + FlixBus	Bus	10:25pm	University of South Florida	1d 1h	11:59pm	Florence, SC	No tags
FlixBus + Greyhound	Bus	10:35pm	Tampa Bus Station	1d 1h	11:59pm	Florence, SC	No tags
FlixBus + Greyhound	Bus	10:35pm	Tampa Bus Station	17h 30m	4:05pm	Bus station	No tags

Compare 2 ways to go from Tampa to Florence

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 18 hours 15 minutes and with fares starting at just $72, it presents an excellent value for a comfortable ride.

4bus per day

18h 15mAverage Duration

451 milesDistance

18kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$72 - $160	Average Duration18h 15m	CO₂ emissions 18kg CO₂e
Train	Average Price$79 - $156	Average Duration18h	CO₂ emissions 67kg CO₂e

Compare bus companies

FlixBus

3.5/511,341 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Amtrak

4/55,588 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Greyhound

3.5/587,377 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Tampa and Florence?

Stops in Tampa

A - Tampa 13th Avenue Bus Stop (McDonald's)

B - Tampa USF, FL

C - Greyhound Station

D - E Sligh Ave

E - N Marion St & E Laurel St

F - Port of Tampa

Stops in Florence

A - Florence Bus Station

B - TA Travel Center - Florence

Frequently asked questions about traveling from Tampa to Florence, SC, US by bus

What is the travel distance from Tampa to Florence?
What are the departure and arrival stations when taking the bus from Tampa to Florence?
What are the best sights and things to do in Florence?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/14

$71

11/15

$73

Today

$71

11/17

$69

11/18

$65

11/19

$67

11/20

No data

11/21

No data

The cheapest trip from Tampa to Florence, SC, US was searched and found on Nov 18, 2025 with a price of $65

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US, as early as possible.

You can expect to pay from $65 to $1,070 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $65 which is on 2025-11-18.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.