Next departures for Philadelphia to Florence on November 12
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Philadelphia (Logan Square)
Florence, SC
Cheapest
Bus
Philadelphia, 199 Spring Garden St
Florence, SC
Fastest
Bus
199 Spring Garden St.
Bus station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
Florence, SC
No tags
Bus
Schuylkill & Walnut
Florence, SC
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Bus station
No tags
Bus
Schuylkill & Walnut
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Bus station
No tags
Next departures for Philadelphia to Florence on November 13
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Bus station
Cheapest
Bus
Philadelphia, 199 Spring Garden St
Florence, SC
Fastest
Bus
199 Spring Garden St.
Bus station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
Florence, SC
No tags
Bus
Cherry Hill Mall
Florence, SC
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Bus station
No tags
Bus
Schuylkill & Walnut
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
Bus station
No tags
Next departures for Philadelphia to Florence on November 14
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Bus station
Cheapest
Bus
Philadelphia, 199 Spring Garden St
Florence, SC
Fastest
Bus
199 Spring Garden St.
Bus station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
Florence, SC
No tags
Bus
Cherry Hill Mall
Florence, SC
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Bus station
No tags
Bus
Schuylkill & Walnut
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
Bus station
No tags
Next departures for Philadelphia to Florence on November 15
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Bus station
Cheapest
Bus
Philadelphia, 199 Spring Garden St
Florence, SC
Fastest
Bus
199 Spring Garden St.
Bus station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
Florence, SC
No tags
Bus
Cherry Hill Mall
Florence, SC
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Bus station
No tags
Bus
Schuylkill & Walnut
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
Bus station
No tags
Next departures for Philadelphia to Florence on November 16
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
199 Spring Garden St.
Bus station
Cheapest
Bus
Philadelphia, 199 Spring Garden St
Florence, SC
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
199 Spring Garden St.
Florence, SC
No tags
Bus
Cherry Hill Mall
Florence, SC
No tags
Bus
Schuylkill & Walnut
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia, 199 Spring Garden St
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Cherry Hill Mall
Bus station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Philadelphia (Logan Square)
Bus station
No tags
Last refresh of the prices: Yesterday at 12:30 AM EST.
Compare 2 ways to go from Philadelphia to Florence
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 10 hours 55 minutes and with fares starting at just $91, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Philadelphia, PA to Florence, SC, US by bus
What is the travel distance from Philadelphia to Florence?
About 467 miles (753 km) separate Philadelphia and Florence.
What are the departure and arrival stations when taking the bus from Philadelphia to Florence?
The majority of buses traveling from Philadelphia to Florence start their journey at Philadelphia Airport and wind up at Florence Bus Station. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Florence?
Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Palazzo Pitti, Tuscan Wine Tour, Museo Galileo - Institute and Museum of the History of Science, Leonardo Da Vinci Museum and Galleria degli Uffizi.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/10
$118
11/11
$78
Today
$136
11/13
$85
11/14
$89
11/15
$78
11/16
$81
11/17
$71
The cheapest trip from Philadelphia, PA to Florence, SC, US was searched and found on Nov 17, 2025 with a price of $71
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Philadelphia, PA to Florence, SC, US, as early as possible.
You can expect to pay from $71 to $139 for a bus ticket from Philadelphia, PA to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $71 which is on 2025-11-17.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Philadelphia, PA to Florence, SC, US?
The bus is the cheapest travel choice for this destination