Bus Tickets from Florence, SC, US to Chicago

Find affordable bus tickets from Florence, SC, US to Chicago with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayAug 26
TomorrowAug 27
ThuAug 28
from $167
FriAug 29
from $171
SatAug 30
from $165
SunAug 31
from $132
MonSep 1
from $145
TueSep 2

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 28 at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: August 29 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 28 at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: August 29 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 28 at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: August 29 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 28 at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: August 29 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 28 at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: August 30 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Florence to Chicago.

Bus
Average Price$87 - $299Average Duration1d 6h
27kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$198 - $603Average Duration1d 11h
100kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Florence to Chicago

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 6 hours 25 minutes and with fares starting at just $87, it presents an excellent value for a comfortable ride.

11bus per day
1d 6hAverage Duration
$87Cheapest ticket
27kgCO₂ emissions

Bus Florence, SC, US to Chicago: Trip Overview

Average ticket price$167
Average bus trip duration1d 6h
Number of daily buses11
Earliest bus departure12:05am
Distance673 miles (1084 km)
Latest bus departure4:15pm

Florence to Chicago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Chicago.

We make sure you can find a bus service from Florence to Chicago from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Florence to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Florence, SC, US - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/24
No data
08/25
$171
Today
No data
08/27
No data
08/28
No data
08/29
$164
08/30
No data
08/31
$162
busbud logoThe cheapest trip from Florence, SC, US to Chicago was searched and found on Aug 31, 2025 with a price of $162

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.

You can expect to pay from $162 to $171 for a bus ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $162 which is on 2025-08-31.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Chicago, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Florence to Chicago that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Florence to Chicago.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Florence, SC, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence, SC, US by bus?

Bus from Chicago to Florence, SC, US

You can also go to Chicago by train

Train from Florence, SC, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence

Popular Buses Connecting Chicago

Buses Leaving from Chicago

Buses Going to Chicago