Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Bus station | Downtown Greyhound Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Yesterday at 10:16 AM EST.
Compare 2 ways to go from Florence to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 3 hours 30 minutes, and with fares starting at just $177, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Chicago?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Florence, SC, US to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Chicago?
The cheapest bus tickets from Florence to Chicago start from $177. The average price for this route is around $312. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Chicago?
The average bus travel time from Florence to Chicago is 1d 3h, covering a distance of 1098 km. The quickest bus can get you there in 1d and is operated by Greyhound.
Which bus companies service the Florence to Chicago route?
What are the earliest and latest departure times for the bus from Florence to Chicago?
The earliest bus departs from Florence to Chicago at 12:05am. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from Florence to Chicago?
A bus trip from Florence to Chicago generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Florence to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Florence to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Chicago was searched and found on Dec 2, 2025 with a price of $216To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.
What's the cheapest way to go from Florence, SC, US to Chicago?
The bus is the cheapest travel choice for this destination
