Find coaches from Tampa to Florence, SC, US

Next departures

Next departures from Tampa to Florence on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Tampa Bus Station
Bus stationCheapest
Amtrak
Union Station
Florence StationFastest
Amtrak
Union Station
Florence StationNo tags
FlixBus + Greyhound Lines, Inc.
Tampa Bus Station
Bus stationNo tags
FlixBus
Tampa Bus Station
Florence, SCNo tags

Last refresh of the prices: Last Sunday at 6:24 PM EDT.

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Compare 2 ways to travel from Tampa to Florence

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 18 hours 15 minutes and with fares starting at just US$72, it presents an excellent value for a comfortable ride.

4bus per day
18h 15mAverage duration
727 kmDistance
18kgCO₂ emissions
Average priceUS$72 - US$160Average duration18h 15m
18kg CO₂e
Average priceUS$79 - US$156Average duration18h
67kg CO₂e

Bus Tampa to Florence, SC, US: Trip Overview

Average ticket priceUS$87
Average bus trip duration18h 15m
Number of daily buses4
Earliest bus departure09:30
Distance726 km
Latest bus departure22:35

Tampa to Florence Bus

Busbud helps you find a bus from Tampa to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tampa to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Tampa, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Tampa - Florence, SC, US

  1. How much does a bus ticket from Tampa to Florence cost?

    The bus ticket price from Tampa to Florence starts at US$72. The best way to find cheap bus tickets from Tampa to Florence is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Tampa to Florence?

    The average travel time between Tampa and Florence is around 18h 15m, although the fastest bus will take about 14h 35m. This is the time it takes to travel the 747 km that separates the two cities.

  3. How many daily bus connections are there between Tampa and Florence?

    The number of buses from Tampa to Florence can differ depending on the day of the week. On average, there are 4 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Tampa to Florence by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Tampa to Florence?

    When taking the bus from Tampa to Florence, you can travel comfortably and safely with FlixBus, Amtrak, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Tampa to Florence?

    Buses travelling between Tampa and Florence leave from Tampa 13th Avenue Bus Stop (McDonald's) or Tampa USF, FL and arrive at Florence Bus Station, TA Travel Center - Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$95
29/10
US$95
Today
US$75
31/10
No data
01/11
US$78
02/11
No data
03/11
US$77
04/11
No data
busbud logoThe cheapest trip from Tampa to Florence, SC, US was searched and found on 30 Oct 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US as early as possible.

You can expect to pay from US$75 to US$872 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$77, which is on 2025-11-03.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tampa and Florence!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tampa to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Florence.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Tampa to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Tampa by bus?

Bus from Florence, SC, US to Tampa

You can also go to Florence, SC, US by train

Train from Tampa to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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