Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Tampa Bus Station | Bus station | Cheapest | |||||
 | Union Station | Florence Station | Fastest | |||||
| Union Station | Florence Station | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Tampa Bus Station | Bus station | No tags | |||||
| Tampa Bus Station | Florence, SC | No tags |
Last refresh of the prices: Last Sunday at 6:24 PM EDT.
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Compare 2 ways to travel from Tampa to Florence
We recommend taking the busAmong the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 18 hours 15 minutes and with fares starting at just US$72, it presents an excellent value for a comfortable ride.
Bus Tampa to Florence, SC, US: Trip Overview
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Tampa to Florence Bus
Busbud helps you find a bus from Tampa to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Tampa to Florence.
Whether it is cheap bus tickets or more luxurious buses going to Florence from Tampa, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Tampa and Florence?
Frequently asked questions on the trip Tampa - Florence, SC, US
How much does a bus ticket from Tampa to Florence cost?
The bus ticket price from Tampa to Florence starts at US$72. The best way to find cheap bus tickets from Tampa to Florence is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Tampa to Florence?
The average travel time between Tampa and Florence is around 18h 15m, although the fastest bus will take about 14h 35m. This is the time it takes to travel the 747 km that separates the two cities.
How many daily bus connections are there between Tampa and Florence?
The number of buses from Tampa to Florence can differ depending on the day of the week. On average, there are 4 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Tampa to Florence by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Tampa to Florence?
When taking the bus from Tampa to Florence, you can travel comfortably and safely with FlixBus, Amtrak, Greyhound.
What are the departure and arrival stations when taking the bus from Tampa to Florence?
Buses travelling between Tampa and Florence leave from Tampa 13th Avenue Bus Stop (McDonald's) or Tampa USF, FL and arrive at Florence Bus Station, TA Travel Center - Florence.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Florence, SC, US was searched and found on 30 Oct 2025 with a price of US$75To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US as early as possible.
You can expect to pay from US$75 to US$872 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$77, which is on 2025-11-03.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tampa and Florence!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tampa to Florence.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Florence.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Florence.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
What's the cheapest way to go from Tampa to Florence, SC, US?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Tampa
Buses Leaving from Tampa
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Buses Going to Tampa
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Popular Buses Connecting Florence
Buses Leaving from Florence
- Bus from Florence to Kansas City
- Coach Florence - Kansas City
- Bus Florence - Oklahoma City
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- Coach Florence - Jackson
- Bus Florence - Jackson
- Bus from Florence to St. Petersburg
- Coach Florence - Rockledge
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- Bus from Florence to Titusville
- Coach Florence - Shreveport
- Bus Florence - Springfield
- Bus from Florence to Elyria
- Coach Florence - Anderson
- Bus Florence - Dallas
Buses Going to Florence
- Bus from Syracuse to Florence
- Coach Manchester - Florence
- Bus Columbus - Florence
- Bus from Columbus to Florence
- Coach Los Angeles - Florence
- Bus Toronto - Florence
- Bus from Albuquerque to Florence
- Coach Valdosta - Florence
- Bus Binghamton - Florence
- Bus from Carbondale to Florence
- Coach Plant City - Florence
- Bus Auburn - Florence
- Bus from Richmond to Florence
- Coach Tampa - Florence
- Bus Allentown - Florence
Popular routes in this country
- Bus from Buffalo to Niagara Falls
- Coach Houston - Brownsville
- Bus New York City - Fleischmanns
- Bus from Miami to Orlando
- Coach Newark - Norfolk
- Bus Milwaukee - Appleton
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