Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Niagara Frontier Transportation Authority | UCSD Health La Jolla Station | No tags | ||||
FlixBus + Greyhound | Bus | Niagara Frontier Transportation Authority | Balboa Park | No tags | ||||
FlixBus + Greyhound | Bus | Niagara Frontier Transportation Authority | Downtown SD (Seaport) | No tags | ||||
FlixBus + Greyhound | Bus | Niagara Frontier Transportation Authority | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound + FlixBus | Bus | Buffalo (BUF) Airport | Downtown SD (Seaport) | No tags |
Compare 2 ways to go from Buffalo to San Diego
Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 2 days, 15 hours 14 minutes and with fares starting at just $351, it presents an excellent value for a comfortable ride.
Where are the popular stops in Buffalo and San Diego?
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Frequently asked questions about traveling from Buffalo, NY to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Buffalo to San Diego?
The cheapest bus tickets from Buffalo to San Diego start from $225. The average price for this route is around $382. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Buffalo to San Diego?
The average bus trip duration from Buffalo to San Diego is 3d 6h, covering a distance of 2184 miles (3523 km). The quickest bus can get you there in 3d 3h and is operated by Greyhound.
Which bus companies service the Buffalo to San Diego route?
What is the earliest and latest departure time for the bus from Buffalo to San Diego?
The earliest bus departs from Buffalo to San Diego at 7:55am. And the latest bus departs at 11:20pm.
What are the CO₂ emissions for the bus trip from Buffalo to San Diego?
A bus trip from Buffalo to San Diego generates an estimated 88 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Buffalo to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Buffalo to San Diego?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Buffalo to San Diego?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Buffalo to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to San Diego, CA, US was searched and found on Dec 10, 2025 with a price of $218To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to San Diego, CA, US, as early as possible.
You can expect to pay from $218 to $218 for a bus ticket from Buffalo, NY to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $218 which is on 2025-12-10.
