Bus Tickets from Buffalo, NY to San Diego, CA, US

Previously seen trips

Next departures for Buffalo to San Diego on October 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Niagara Frontier Transportation Authority
UCSD Health La Jolla StationNo tags
FlixBus + Greyhound
Buffalo (BUF) Airport
San Diego (Old Town-FlixBus)No tags
FlixBus + Greyhound
Buffalo (BUF) Airport
Downtown SD (Seaport)No tags
FlixBus + Greyhound
Buffalo (BUF) Airport
Greyhound Bus StopNo tags
FlixBus + Greyhound
Buffalo (BUF) Airport
UCSD Health La Jolla StationNo tags

Accepted payments

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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Buffalo, NY to San Diego, CA, US: Trip Overview

Average Ticket PriceUS$275
Average Bus Trip Duration3d 7h
Number of daily buses12
Earliest bus departure12:55am
Distance3527 km
Latest bus departure11:59pm

Buffalo to San Diego Bus

Busbud helps you find a bus from Buffalo to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Buffalo to San Diego.

From cheap bus tickets to more luxurious buses travelling from Buffalo to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Buffalo, NY - San Diego, CA, US

  1. What is the travel distance from Buffalo to San Diego?

    It's about 3518 km (2181 miles) from Buffalo to San Diego.

  2. What are the departure and arrival locations for buses traveling from Buffalo to San Diego?

    Buses departing from Buffalo Airport in Buffalo will take you to Mission Valley Sheraton in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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10-08
US$246
busbud logoThe cheapest trip from Buffalo, NY to San Diego, CA, US was searched and found on Oct 8, 2025 with a price of US$246

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to San Diego, CA, US, as early as possible.

You can expect to pay from US$246 to US$246 for a bus ticket from Buffalo, NY to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$246 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and San Diego!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Buffalo to San Diego.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Buffalo to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Buffalo, NY by bus?

Bus from San Diego, CA, US to Buffalo, NY

You can also go to San Diego, CA, US by train

Train from Buffalo, NY to San Diego, CA, US

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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