Bus Tickets from Boston, MA, US to Greenville, SC

ThuAug 7
from $193
FriAug 8
SatAug 9
from $149
SunAug 10
MonAug 11
TueAug 12
WedAug 13
ThuAug 14

Cheap buses leaving Saturday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: August 9 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 11 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: August 9 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 10 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 10 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: Boston
    Departure location: Boston (South Station)
    Arrival time: August 10 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 9 at
    Departure city: Boston
    Departure location: Brookline
    Arrival time: August 10 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from Boston to Greenville.

Average Price$85 - $286Average Duration23h 5m
32kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Average Price$197 - $594Average Duration20h 56m
117kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Boston to Greenville

Among the sustainable travel choices, the train stands out as the good way to reach Greenville. The journey takes about 20 hours 56 minutes and with fares starting at just $197, it presents an excellent value for a comfortable ride.

3train per day
20h 56mAverage Duration
$197Cheapest ticket
117kgCO₂ emissions

Bus Boston, MA, US to Greenville, SC: Trip Overview

Average ticket price$130
Average bus trip duration23h 5m
Number of daily buses9
Earliest bus departure1:30am
Distance797 miles (1285 km)
Latest bus departure10:00pm

Boston to Greenville Bus

Busbud helps you find a bus from Boston to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Boston to Greenville will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Boston, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Boston, MA, US - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/03
$170
08/04
$144
Today
$111
08/06
$218
08/07
$206
08/08
$136
08/09
$153
08/10
$117
busbud logoThe cheapest trip from Boston, MA, US to Greenville, SC was searched and found on Aug 5, 2025 with a price of $111

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Boston, MA, US to Greenville, SC, as early as possible.

You can expect to pay from $111 to $234 for a bus ticket from Boston, MA, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $117 which is on 2025-08-10.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Boston and Greenville!

Much more than a mere vehicle taking you from Boston to Greenville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Boston to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Boston to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Boston, MA, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Boston, MA, US by bus?

Bus from Boston, MA, US to Greenville, SC

You can also go to Greenville, SC by train

Train from Boston, MA, US to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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