Bus Tickets from Columbus, OH to Greenville, SC

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ThuAug 7
from US$96
FriAug 8
SatAug 9
SunAug 10
MonAug 11
TueAug 12
WedAug 13
ThuAug 14

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 7 at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: August 8 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 7 at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: August 7 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 7 at
    Departure city: Columbus
    Departure location: 100 E Rich St
    Arrival time: August 8 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 7 at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: August 7 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 7 at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: August 8 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Thursday at 12:36 PM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Columbus, OH to Greenville, SC: Trip Overview

Average Ticket PriceUS$125
Average Bus Trip Duration21h 45m
Number of daily buses6
Earliest bus departure12:45am
Distance573 km
Latest bus departure11:30pm

Columbus to Greenville Bus

Busbud helps you find a bus from Columbus to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Columbus to Greenville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Columbus to Greenville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Columbus, OH - Greenville, SC

  1. How far is Columbus from Greenville?

    It's about 572 km (355 miles) from Columbus to Greenville.

  2. What are the departure and arrival locations for buses traveling from Columbus to Greenville?

    Buses departing from Columbus Bus Station in Columbus will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-03
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08-04
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Today
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08-06
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08-07
US$89
08-08
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08-10
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busbud logoThe cheapest trip from Columbus, OH to Greenville, SC was searched and found on Aug 7, 2025 with a price of US$89

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Greenville, SC, as early as possible.

You can expect to pay from US$89 to US$90 for a bus ticket from Columbus, OH to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$89 which is on 2025-08-07.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Columbus and Greenville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Columbus to Greenville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Columbus to Greenville will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Columbus to Greenville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Columbus, OH by bus?

Bus from Columbus, OH to Greenville, SC

Why choose Busbud?

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