Find coaches from Columbus, OH to Greenville, SC

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Today10 Aug
Tomorrow11 Aug
Tue12 Aug
Wed13 Aug
from US$76
Thu14 Aug
Fri15 Aug
Sat16 Aug
from US$81
Sun17 Aug

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 13 August at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: 13 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 13 August at
    Departure city: Columbus
    Departure location: 100 E Rich St
    Arrival time: 14 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 13 August at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: 14 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 13 August at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: 14 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 13 August at
    Departure city: Columbus
    Departure location: Columbus (E Mound St)
    Arrival time: 14 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Columbus, OH to Greenville, SC: Trip Overview

Average ticket priceUS$105
Average bus trip duration21h 45m
Number of daily buses5
Earliest bus departure00:45
Distance356 miles
Latest bus departure23:30

Columbus to Greenville Bus

Busbud helps you find a bus from Columbus to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Columbus to Greenville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Columbus to Greenville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Columbus, OH - Greenville, SC

  1. What's the distance between Columbus and Greenville by coach?

    The journey from Columbus to Greenville by coach covers an approximate distance of 355 miles (572 km).

  2. How can I travel from Columbus to Greenville avoiding air travel?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/08
No data
09/08
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Today
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11/08
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12/08
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13/08
US$68
14/08
No data
15/08
No data
busbud logoThe cheapest trip from Columbus, OH to Greenville, SC was searched and found on 13 Aug 2025 with a price of US$68

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Greenville, SC as early as possible.

You can expect to pay from US$68 to US$71 for a bus ticket from Columbus, OH to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$68, which is on 2025-08-13.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Columbus and Greenville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Columbus to Greenville, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Columbus to Greenville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Columbus to Greenville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Columbus, OH by bus?

Bus from Columbus, OH to Greenville, SC

Why choose Busbud?

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