Bus Tickets from Syracuse, US to Chicago

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TodaySep 10
from $90
TomorrowSep 11
from $91
FriSep 12
from $99
SatSep 13
from $99
SunSep 14
from $76
MonSep 15
from $82
TueSep 16
from $75
WedSep 17
from $60

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 11 at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: September 11 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 11 at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: September 11 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 11 at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: September 12 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 11 at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: September 12 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 11 at
    Departure city: Syracuse
    Departure location: Syracuse (Regional Transportation Center)
    Arrival time: September 12 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Syracuse to Chicago.

Bus
Average Price$60 - $263Average Duration1d 3h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$60 - $215Average Duration13h 7m
86kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Syracuse to Chicago

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 3 hours 35 minutes and with fares starting at just $60, it presents an excellent value for a comfortable ride.

7bus per day
1d 3hAverage Duration
$60Cheapest ticket
24kgCO₂ emissions

Bus Syracuse, US to Chicago: Trip Overview

Average ticket price$94
Average bus trip duration1d 3h
Number of daily buses7
Earliest bus departure12:20am
Distance589 miles (950 km)
Latest bus departure9:00pm

Syracuse to Chicago Bus

Busbud helps you find a bus from Syracuse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Syracuse to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Syracuse to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Syracuse, US - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/08
$83
09/09
$102
Today
$78
09/11
$83
09/12
$92
09/13
$92
09/14
$68
09/15
$74
busbud logoThe cheapest trip from Syracuse, US to Chicago was searched and found on Sep 14, 2025 with a price of $68

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.

You can expect to pay from $68 to $157 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $68 which is on 2025-09-14.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Chicago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Syracuse to Chicago will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Syracuse to Chicago.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Syracuse, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Syracuse, US by bus?

Bus from Chicago to Syracuse, US

You can also go to Chicago by train

Train from Syracuse, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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