Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | CheapestFastest | ||||
| Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | ||||
| Bus | Syracuse (Regional Transportation Center) | 537-517 W. Jackson Blvd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Today at 12:37 AM EST.
Compare 2 ways to go from Syracuse to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours, and with fares starting at just $81, it presents an excellent value for a comfortable ride.
9bus per day
1d 5hAverage Duration
952 kmDistance
24kgCO₂ emissions
Compare bus companies
3.5 out of 5 stars3.5/587,374 reviews
3.5 out of 5 stars3.5/511,326 reviews
4 out of 5 stars4/54,411 reviews
4 out of 5 stars4/51,125 reviews
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Syracuse and Chicago?
Stops in Syracuse
Stops in Chicago
Frequently asked questions about travelling from Syracuse, US to Chicago by bus
What is the travel distance from Syracuse to Chicago?
The distance covered from Syracuse to Chicago is 954 km (592 miles).
What are the departure and arrival locations for buses traveling from Syracuse to Chicago?
Buses traveling this route start their trip at Regional Transportation Center, in Syracuse, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-13
$205
11-14
$212
Today
$192
11-16
$180
11-17
$157
11-18
$162
11-19
$168
11-20
$198
The cheapest trip from Syracuse, US to Chicago was searched and found on Nov 17, 2025 with a price of $157To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.
You can expect to pay from $157 to $300 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2025-11-17.
What's the cheapest way to go from Syracuse, US to Chicago?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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