Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | Cheapest | |||||
| Syracuse (Regional Transportation Center) | Downtown Greyhound Station | Fastest | |||||
| Syracuse (Regional Transportation Center) | Downtown Greyhound Station | No tags | |||||
| Syracuse (Regional Transportation Center) | 537-517 W. Jackson Blvd | No tags | |||||
| Syracuse (Regional Transportation Center) | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 4:57 PM EDT.
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Compare 2 ways to go from Syracuse to Chicago
Busbud recommends taking the train from Syracuse to ChicagoAmong the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 13 hours 7 minutes, and with fares starting at just US$60, it presents an excellent value for a comfortable ride.
Bus Syracuse, US to Chicago: Trip Overview
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Syracuse to Chicago Bus
Busbud helps you find a bus from Syracuse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Syracuse to Chicago from the most reliable bus companies operating this trip.
Discover how much the bus trip from Syracuse to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Syracuse and Chicago?
Frequently asked questions on the trip Syracuse, US - Chicago
What is the travel distance from Syracuse to Chicago?
The distance covered from Syracuse to Chicago is 954 km (592 miles).
What are the departure and arrival locations for buses traveling from Syracuse to Chicago?
Buses traveling this route start their trip at Syracuse Airport, in Syracuse, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Chicago was searched and found on Sep 28, 2025 with a price of US$65To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.
You can expect to pay from US$65 to US$181 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$65 which is on 2025-09-28.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Chicago!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to Chicago, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Syracuse to Chicago will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Syracuse to Chicago.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
What's the cheapest way to go from Syracuse, US to Chicago?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Popular Buses Connecting Syracuse
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Popular Buses Connecting Chicago
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Popular routes in this country
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