Bus Tickets from Santa Ana, US to Chicago

Next departures

Next departures for Santa Ana to Chicago on October 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Anaheim Regional Transportation Intermodal Center
Downtown Greyhound StationCheapestFastest
Greyhound Lines, Inc.
Anaheim Regional Transportation Intermodal Center
Downtown Greyhound StationNo tags
FlixBus + Greyhound Lines, Inc.
UC Irvine (Crawford Hall)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
Anaheim Regional Transportation Intermodal Center
537-517 W. Jackson BlvdNo tags
FlixBus + Greyhound Lines, Inc.
UC Irvine (Crawford Hall)
Downtown Greyhound StationNo tags

Last refresh of the prices: Yesterday at 1:11 PM PDT.

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Bus Santa Ana, US to Chicago: Trip Overview

Average ticket price$256
Average bus trip duration2d 6h
Number of daily buses10
Earliest bus departure8:45am
Distance1728 miles (2787 km)
Latest bus departure9:40pm

Santa Ana to Chicago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Ana to Chicago.

We make sure you can find a bus service from Santa Ana to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santa Ana to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Santa Ana, US - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/01
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10/02
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Today
$277
10/04
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10/05
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busbud logoThe cheapest trip from Santa Ana, US to Chicago was searched and found on Oct 3, 2025 with a price of $277

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to Chicago, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Ana to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Ana to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santa Ana to Chicago will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santa Ana to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Santa Ana, US by bus?

Bus from Chicago to Santa Ana, US

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