Bus Tickets from Roanoke to Knoxville, TN

Previously seen trips

Next departures for Roanoke to Knoxville on October 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Roanoke Bus Stop
Knoxville Bus StationNo tags
Greyhound
Roanoke Bus Stop
Knoxville Bus StationNo tags
Greyhound
Roanoke Bus Stop
Knoxville Bus StationNo tags
Greyhound
Roanoke Bus Stop
Knoxville Bus StationNo tags
Greyhound
Roanoke Bus Stop
Knoxville Bus StationNo tags

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Bus Roanoke to Knoxville, TN: Trip Overview

Average ticket price$46
Average bus trip duration5h 15m
Number of daily buses1
Earliest bus departure12:50pm
Distance235 miles (378 km)

Roanoke to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Roanoke to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Roanoke to Knoxville.

From cheap bus tickets to more luxurious buses traveling from Roanoke to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Roanoke - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/30
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10/01
$36
Today
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10/03
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10/04
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10/05
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10/06
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10/07
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busbud logoThe cheapest trip from Roanoke to Knoxville, TN was searched and found on Oct 1, 2025 with a price of $36

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Knoxville, TN, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Roanoke to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Roanoke to Knoxville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Roanoke to Knoxville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Roanoke to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Roanoke by bus?

Bus from Knoxville, TN to Roanoke

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