Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Lyon - Perrache Bus Station | Karlsruhe | Cheapest | |||||
 | Perrache | Südseite Hauptbahnhof | Fastest | |||||
| Lyon - Perrache Bus Station | Karlsruhe | No tags | |||||
| Perrache | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Perrache | Karlsruhe Hbf | No tags |
Last refresh of the prices: Last Tuesday at 7:15 AM CET.
Compare 3 ways to go from Lyon to Karlsruhe
Among the sustainable travel choices, the carpool stands out as the good way to reach Karlsruhe. The journey takes about 5 hours 30 minutes and with fares starting at just $49, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lyon and Karlsruhe?
Stops in Lyon
- ARue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Compare bus companies
Frequently asked questions about traveling from Lyon to Karlsruhe by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Lyon to Karlsruhe?
The cheapest bus tickets from Lyon to Karlsruhe start from $26. The average price for this route is around $49. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Lyon to Karlsruhe?
The average bus trip duration from Lyon to Karlsruhe is 8h 40m, covering a distance of 279 miles (450 km). The quickest bus can get you there in 7h 55m and is operated by FlixBus.
Which bus companies service the Lyon to Karlsruhe route?
Several major bus companies operate on this route with 2 buses available per day, including services from FlixBus, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Lyon to Karlsruhe?
The earliest bus departs from Lyon to Karlsruhe at 12:20am. And the latest bus departs at 11:00pm.
What are the CO₂ emissions for the bus trip from Lyon to Karlsruhe?
A bus trip from Lyon to Karlsruhe generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Lyon to Karlsruhe?
According to Busbud customers, the highest-rated bus company on this route is BlaBlaCar Bus, with an average rating of 3.7 out of 5 stars based on 11143 reviews.
Which bus company has the best Wi-Fi from Lyon to Karlsruhe?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Lyon to Karlsruhe?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Lyon to Karlsruhe?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is BlaBlaCar Bus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Karlsruhe was searched and found on Dec 2, 2025 with a price of $24To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Karlsruhe, as early as possible.
You can expect to pay from $24 to $130 for a bus ticket from Lyon to Karlsruhe based on the last 2 days. You can expect to find the cheapest price for the trip at $24 which is on 2025-12-02.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Lyon to Karlsruhe?
The bus is the cheapest travel choice for this destination
