Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Perrache | Südseite Hauptbahnhof | Cheapest | |||||
Flixbus + Flixtrain | Perrache | Karlsruhe Hbf | Fastest | |||||
 | Lyon - Perrache Bus Station | Karlsruhe | No tags | |||||
| Perrache | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Perrache | Karlsruhe Hbf | No tags |
Accepted payments
Compare 3 ways to go from Lyon to Karlsruhe
| Average Price | Average Duration | CO₂ emissions | |||
|---|---|---|---|---|---|
| Average PriceUS$26 - US$151 | Average Duration9h 10m | 11kg CO₂e5 out of 5 stars | CheapestMost eco-friendly | ||
| Average PriceUS$100 - US$225 | Average Duration5h 21m | 11kg CO₂e5 out of 5 stars | Fastest | ||
Carpool | Average PriceUS$38 - US$86 | Average Duration5h 40m | 19kg CO₂e4 out of 5 stars |
Busbud recommends carpooling from Lyon to KarlsruheAmong the sustainable travel choices, the carpool stands out as a good way to reach Karlsruhe. The journey takes about 5 hours 40 minutes, and with fares starting at just US$38, it presents an excellent value for a comfortable ride.
Bus Lyon to Karlsruhe: Trip Overview
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Lyon to Karlsruhe Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Lyon to Karlsruhe.
Bus service from Lyon to Karlsruhe will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses travelling from Lyon to Karlsruhe, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Lyon and Karlsruhe?
Frequently asked questions on the trip Lyon - Karlsruhe
What is the travel distance from Lyon to Karlsruhe?
The distance between Lyon and Karlsruhe is approximately 450 km (279 miles).
What are the departure and arrival locations for buses traveling from Lyon to Karlsruhe?
Buses departing from Perrache in Lyon will take you to Südseite Hauptbahnhof in Karlsruhe.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Karlsruhe was searched and found on Sep 15, 2025 with a price of US$25To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Karlsruhe, as early as possible.
You can expect to pay from US$25 to US$61 for a bus ticket from Lyon to Karlsruhe based on the last 2 days. You can expect to find the cheapest price for the trip at US$25 which is on 2025-09-21.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Lyon to Karlsruhe but it'll also be endearing to native speakers who will surely appreciate your effort.
Much more than a mere vehicle taking you from Lyon to Karlsruhe, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Lyon to Karlsruhe that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Lyon to Karlsruhe while indulging in miles on end of beautiful scenic views.
Did you know?
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
What's the cheapest way to go from Lyon to Karlsruhe?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Lyon
Buses Leaving from Lyon
- Bus from Lyon to Marseille
- Bus Lyon - Saint-Étienne
- Lyon - Lens
- Bus from Lyon to Reims
- Bus Lyon - Rennes
- Lyon - Auxerre
- Bus from Lyon to Chamonix Mont Blanc
- Bus Lyon - L'Alpe-d'Huez
- Lyon - Annecy
- Bus from Lyon to Nice
- Bus Lyon - Paris
- Lyon - Tignes
- Bus from Lyon to Toulouse
- Bus Lyon - Les Deux Alpes
- Lyon - Chambéry
Buses Going to Lyon
- Bus from Saint-Étienne to Lyon
- Bus Toulouse - Lyon
- Nice - Lyon
- Bus from Le Havre to Lyon
- Bus Montpellier - Lyon
- Brest - Lyon
- Bus from Chamonix Mont Blanc to Lyon
- Bus Annecy - Lyon
- Grenoble - Lyon
- Bus from Versailles to Lyon
- Bus Lorient - Lyon
- Marseille - Lyon
- Bus from Avignon to Lyon
- Bus Strasbourg - Lyon
- Bordeaux - Lyon
Popular Buses Connecting Karlsruhe
Buses Leaving from Karlsruhe
- Bus from Karlsruhe to Kaiserslautern
- Bus Karlsruhe - Regensburg
- Karlsruhe - Paris
- Bus from Karlsruhe to Stuttgart
- Bus Karlsruhe - Hamburg
- Karlsruhe - Paderborn
- Bus from Karlsruhe to Freiburg
- Bus Karlsruhe - Montabaur
- Karlsruhe - Berlin
- Bus from Karlsruhe to Erfurt
- Bus Karlsruhe - Puttgarden
- Karlsruhe - Friedrichshafen
- Bus from Karlsruhe to Heidelberg
- Bus Karlsruhe - Jena
- Karlsruhe - Gelsenkirchen
Buses Going to Karlsruhe
- Bus from Darmstadt to Karlsruhe
- Bus Paderborn - Karlsruhe
- Regensburg - Karlsruhe
- Bus from Mannheim to Karlsruhe
- Bus Cologne - Karlsruhe
- Wertheim - Karlsruhe
- Bus from Munich to Karlsruhe
- Bus Bremen - Karlsruhe
- Bonn - Karlsruhe
- Bus from Berlin to Karlsruhe
- Bus Offenburg - Karlsruhe
- Stuttgart - Karlsruhe
- Bus from Heidelberg to Karlsruhe
- Bus Memmingen - Karlsruhe
- Düsseldorf - Karlsruhe
Popular routes in this country
- Bus from Grenoble to Valence
- Bus Toulouse - Lourdes
- Toulouse - Marseille
- Bus from Montélimar to Marseille
- Bus Toulouse - Carcassonne
- Nice - Antibes
- Bus from Toulouse to Hendaye
- Bus Beauvais - Paris
- Toulouse - Bordeaux
- Bus from Paris to Bordeaux
- Bus Paris - Lyon
- Toulouse - Lille
- Bus from Paris to Toulouse
- Bus Strasbourg - Bordeaux
- Toulouse - Limoges