Bus Tickets from Iowa City to St. Louis

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TodayAug 30
TomorrowAug 31
MonSep 1
TueSep 2
from $103
WedSep 3
from $103
ThuSep 4
from $103
FriSep 5
SatSep 6

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: September 2 at
    Departure city: Iowa City
    Departure location: Iowa City
    Arrival time: September 2 at
    Destination city: St. Louis
    Destination location: Gateway Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Iowa City to St. Louis: Trip Overview

Average ticket price$103
Average bus trip duration15h 15m
Number of daily buses1
Earliest bus departure7:50am
Distance221 miles (356 km)
Latest bus departure9:55am

Iowa City to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Iowa City to St. Louis.

Bus service from Iowa City to St. Louis will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Iowa City to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Iowa City - St. Louis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/28
No data
08/29
No data
Today
$86
08/31
No data
09/01
$86
09/02
No data
09/03
No data
09/04
No data
busbud logoThe cheapest trip from Iowa City to St. Louis was searched and found on Aug 30, 2025 with a price of $86

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Iowa City to St. Louis, as early as possible.

You can expect to pay from $86 to $118 for a bus ticket from Iowa City to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $86 which is on 2025-09-01.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Iowa City to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Iowa City to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Iowa City to St. Louis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Iowa City to St. Louis.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Iowa City by bus?

Bus from St. Louis to Iowa City

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