Find coaches from Indianapolis to San Diego, CA, US

Next departures

Next departures from Indianapolis to San Diego on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Indianapolis Northeast
Greyhound Bus StopCheapest
Greyhound Lines, Inc. + FlixBus
Indianapolis Bus Station
UCSD Health La Jolla StationFastest
Greyhound Lines, Inc. + FlixBus
Indianapolis Bus Station
San Diego (Old Town-FlixBus)No tags
Greyhound Lines, Inc.
Indianapolis Bus Station
Greyhound Bus StopNo tags
Greyhound Lines, Inc. + FlixBus
Indianapolis Bus Station
San Diego (Old Town-FlixBus)No tags

Last refresh of the prices: Last Monday at 4:38 PM EDT.

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Compare 2 ways to travel from Indianapolis to San Diego

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 13 hours 25 minutes and with fares starting at just US$155, it presents an excellent value for a comfortable ride.

24bus per day
2d 13hAverage duration
2875 kmDistance
72kgCO₂ emissions
Bus
Average priceUS$155 - US$557Average duration2d 13h
72kg CO₂e
Train
Average priceUS$267 - US$413Average duration2d 10h
262kg CO₂e

Bus Indianapolis to San Diego, CA, US: Trip Overview

Average ticket priceUS$260
Average bus trip duration2d 13h
Number of daily buses24
Earliest bus departure03:15
Distance2875 km
Latest bus departure23:30

Indianapolis to San Diego Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to San Diego from the most reliable bus companies operating this trip.

Discover how much the bus trip from Indianapolis to San Diego will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Indianapolis - San Diego, CA, US

  1. How much does a bus ticket from Indianapolis to San Diego cost?

    The bus ticket price from Indianapolis to San Diego starts at US$155. The best way to find cheap bus tickets from Indianapolis to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Indianapolis to San Diego?

    The average travel time between Indianapolis and San Diego is around 2d 13h, although the fastest bus will take about 2d . This is the time it takes to travel the 2876 km that separates the two cities.

  3. How many daily bus connections are there between Indianapolis and San Diego?

    The number of buses from Indianapolis to San Diego can differ depending on the day of the week. On average, there are 24 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Indianapolis to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Indianapolis to San Diego?

    When taking the bus from Indianapolis to San Diego, you can travel comfortably and safely with Greyhound, FlixBus, Amtrak.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$269
29/10
US$469
Today
US$327
31/10
US$285
01/11
US$185
02/11
US$272
03/11
No data
04/11
No data
busbud logoThe cheapest trip from Indianapolis to San Diego, CA, US was searched and found on 01 Nov 2025 with a price of US$185

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US as early as possible.

You can expect to pay from US$185 to US$469 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$185, which is on 2025-11-01.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to San Diego, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Indianapolis to San Diego will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Indianapolis to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Indianapolis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from San Diego, CA, US to Indianapolis

You can also go to San Diego, CA, US by train

Train from Indianapolis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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