Bus Tickets from Indianapolis to San Diego, CA, US

Previously seen trips

Next departures for Indianapolis to San Diego on September 26
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Downtown Transit Center
Balboa ParkNo tags
FlixBus + Greyhound
Downtown Transit Center
Greyhound Bus StopNo tags
FlixBus + Greyhound
Downtown Transit Center
Downtown SD (Seaport)No tags
FlixBus + Greyhound
Downtown Transit Center
San Diego (Old Town-FlixBus)No tags
FlixBus + Greyhound
Downtown Transit Center
UCSD Health La Jolla StationNo tags

Accepted payments

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Compare 2 ways to go from Indianapolis to San Diego

Bus
Average PriceUS$151 - US$433Average Duration2d 11h
72kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$207 - US$346Average Duration2d 9h
262kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Indianapolis to San Diego

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 2 days, 9 hours 53 minutes, and with fares starting at just US$207, it presents an excellent value for a comfortable ride.

2train per day
2d 9hAverage Duration
US$207Cheapest ticket
262kgCO₂ emissions

Bus Indianapolis to San Diego, CA, US: Trip Overview

Average Ticket PriceUS$207
Average Bus Trip Duration2d 11h
Number of daily buses19
Earliest bus departure3:30am
Distance2882 km
Latest bus departure11:30pm

Indianapolis to San Diego Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to San Diego from the most reliable bus companies operating this trip.

Discover how much the bus trip from Indianapolis to San Diego will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Indianapolis - San Diego, CA, US

  1. What is the distance between Indianapolis and San Diego?

    It's about 2876 km (1783 miles) from Indianapolis to San Diego.

  2. What are the departure and arrival locations for buses traveling from Indianapolis to San Diego?

    Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Mission Valley Sheraton, in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-24
US$357
09-25
No data
Today
No data
09-27
No data
09-28
No data
09-29
No data
09-30
No data
10-01
No data
busbud logoThe cheapest trip from Indianapolis to San Diego, CA, US was searched and found on Sep 24, 2025 with a price of US$357

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to San Diego, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to San Diego will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Indianapolis to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Indianapolis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from San Diego, CA, US to Indianapolis

You can also go to San Diego, CA, US by train

Train from Indianapolis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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