How much is the bus ticket from Indianapolis to San Diego?

The cheapest coach tickets from Indianapolis to San Diego start from £102. The average price for this route is around £184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus journey from Indianapolis to San Diego?

The average bus journey time from Indianapolis to San Diego is 2d 11h, covering a distance of 1780 miles. The fastest bus can take you there in 2d and is operated by Greyhound .

Which bus companies service the Indianapolis to San Diego route?

Several major bus companies operate on this route with 24 buses available per day, including services from Greyhound , FlixBus , Amtrak .

What is the earliest and latest departure time for the bus from Indianapolis to San Diego?

The earliest bus departs from Indianapolis to San Diego at 03:15. And the latest bus departs at 23:30.

What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?

A bus journey from Indianapolis to San Diego produces an estimated 72 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

Which is the best bus company from Indianapolis to San Diego?

According to Busbud customers, the highest-rated bus company on this route is Amtrak , with an average rating of 4.1 out of 5 stars based on 5752 reviews.

Which company has the best Wi-Fi from Indianapolis to San Diego?

Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

Which bus company offers the most punctual service from Indianapolis to San Diego?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 4.0 out of 5 stars.

Which bus company has the cleanest buses from Indianapolis to San Diego?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak , with a cleanliness rating of 4.5 out of 5 stars.

Bus Indianapolis to San Diego from £118 | Refundable Tickets

Next bus departures

Next departures from Indianapolis to San Diego on 13 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	3d 1h	18:10	San Diego (Old Town-FlixBus)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 5h	22:15	Downtown SD (Seaport)	No tags

Next departures from Indianapolis to San Diego on 14 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	23:30	Downtown Transit Center	2d 15h	11:45	Greyhound Bus Stop	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 15 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 7h	15:55	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 8h	16:25	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 16 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	23:30	Downtown Transit Center	2d 17h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 8h	16:25	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d 6h	23:50	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 17 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	13:40	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d 6h	23:50	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 18 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	13:40	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 19 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	2d 16h	10:05	Downtown SD (Seaport)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Last refresh of the prices: Last Wednesday at 08:09 EST.

Compare 2 ways to travel from Indianapolis to San Diego

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach San Diego. The journey takes about 2 days, 11 hours 5 minutes and with fares starting at just £102, it presents an excellent value for a comfortable ride.

24bus per day

2d 11hAverage duration

1780 milesDistance

72kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£102 - £513	Average duration2d 11h	CO₂ emissions 72kg CO₂e
Train	Average price£263 - £264	Average duration2d 9h	CO₂ emissions 262kg CO₂e

Where are the popular stops in Indianapolis and San Diego?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,522 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/512,208 reviews

Staff4.2

Timeliness4

Cleanliness4.1

Wi‑Fi2.7

Amtrak

4/55,759 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wi‑Fi3.6

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling by bus from Indianapolis to San Diego, CA, US

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much is the bus ticket from Indianapolis to San Diego?
The cheapest coach tickets from Indianapolis to San Diego start from £102. The average price for this route is around £184. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Indianapolis to San Diego?
The average bus journey time from Indianapolis to San Diego is 2d 11h, covering a distance of 1780 miles. The fastest bus can take you there in 2d and is operated by Greyhound.
Which bus companies service the Indianapolis to San Diego route?
Several major bus companies operate on this route with 24 buses available per day, including services from Greyhound, FlixBus, Amtrak.
What is the earliest and latest departure time for the bus from Indianapolis to San Diego?
The earliest bus departs from Indianapolis to San Diego at 03:15. And the latest bus departs at 23:30.
What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?
A bus journey from Indianapolis to San Diego produces an estimated 72 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Indianapolis to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5752 reviews.
Which company has the best Wi-Fi from Indianapolis to San Diego?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Indianapolis to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/02

£334

12/02

£313

Today

£239

14/02

£296

15/02

£118

16/02

£165

17/02

£205

18/02

£224

The cheapest trip from Indianapolis to San Diego, CA, US was searched and found on 15 Feb 2026 with a price of £118

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US as early as possible.

You can expect to pay from £118 to £334 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £118, which is on 2026-02-15.