Find coaches from Jefferson City, MO to Knoxville, TN

Find affordable coach tickets from Jefferson City, MO to Knoxville, TN with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.

Previously seen journeys

One passenger / one way

  • Departure time: 15 March at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: 16 March at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 28 August at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: 29 August at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 28 August at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: 29 August at
    Destination city: Knoxville
    Destination location: 100 Kirkwood St
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 2 September at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: 3 September at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: 4 September at
    Departure city: Jefferson City
    Departure location: Jefferson City
    Arrival time: 5 September at
    Destination city: Knoxville
    Destination location: 100 Kirkwood St
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Jefferson City, MO to Knoxville, TN: Trip Overview

Average ticket priceUS$99
Average bus trip duration23h
Number of daily buses1
Earliest bus departure19:15
Distance487 miles

Jefferson City to Knoxville Bus

Busbud helps you find a bus from Jefferson City to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Jefferson City to Knoxville.

Discover how much the bus trip from Jefferson City to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Jefferson City, MO - Knoxville, TN

  1. What's the distance between Jefferson City and Knoxville by coach?

    The journey from Jefferson City to Knoxville by coach covers an approximate distance of 486 miles (784 km).

  2. How can I travel from Jefferson City to Knoxville avoiding air travel?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/08
No data
30/08
No data
Today
No data
01/09
No data
02/09
US$92
03/09
No data
04/09
No data
05/09
No data
busbud logoThe cheapest trip from Jefferson City, MO to Knoxville, TN was searched and found on 2 Sept 2025 with a price of US$92

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jefferson City, MO to Knoxville, TN as early as possible.

You can expect to pay from US$92 to US$92 for a bus ticket from Jefferson City, MO to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$92, which is on 2025-09-02.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Jefferson City and Knoxville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Jefferson City to Knoxville.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Jefferson City to Knoxville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Jefferson City to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Jefferson City, MO by bus?

Bus from Knoxville, TN to Jefferson City, MO

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Jefferson City

Buses Leaving from Jefferson City

Buses Going to Jefferson City

Popular Buses Connecting Knoxville

Buses Leaving from Knoxville

Buses Going to Knoxville