Bus St. Louis to Louisville: Trip Overview
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St. Louis to Louisville Bus
With Busbud, comparing and booking tickets for a bus from St. Louis to Louisville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from St. Louis to Louisville from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Louisville from St. Louis, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in St. Louis and Louisville?
Frequently asked questions on the trip St. Louis - Louisville
What is the distance between St. Louis and Louisville?
The distance between St. Louis and Louisville is around 390 km (242 miles).
What are the departure and arrival locations for buses traveling from St. Louis to Louisville?
Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at Louisville Greyhound Bus Station, in Louisville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Louisville was searched and found on Aug 7, 2025 with a price of US$46To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Louisville, as early as possible.
You can expect to pay from US$46 to US$64 for a bus ticket from St. Louis to Louisville based on the last 2 days. You can expect to find the cheapest price for the trip at US$56 which is on 2025-08-10.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from St. Louis to Louisville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Louisville, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Louisville.
Make a music playlist for your bus ride from St. Louis to Louisville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Top travelled bus routes
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