Bus Tickets from San Diego, CA, US to Buffalo, NY

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TodayJun 24
TomorrowJun 25
from US$248
ThuJun 26
FriJun 27
SatJun 28
SunJun 29
MonJun 30
TueJul 1

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 25 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: June 29 at
    Destination city: Buffalo
    Destination location: Buffalo (BUF) Airport
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 25 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: June 28 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: June 28 at
    Destination city: Buffalo
    Destination location: Buffalo (BUF) Airport
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: June 28 at
    Destination city: Buffalo
    Destination location: Niagara Frontier Transportation Authority
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: San Diego
    Departure location: UCSD Health La Jolla Station
    Arrival time: June 28 at
    Destination city: Buffalo
    Destination location: Buffalo (BUF) Airport
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Today at 8:15 AM PDT.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from San Diego to Buffalo

Bus
Average PriceUS$238 - US$442Average Duration3d 8h
88kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$281 - US$417Average Duration2d 15h
321kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from San Diego to Buffalo

Among the sustainable travel choices, the train stands out as a good way to reach Buffalo. The journey takes about 2 days, 15 hours 52 minutes, and with fares starting at just US$281, it presents an excellent value for a comfortable ride.

4train per day
2d 15hAverage Duration
US$281Cheapest ticket
321kgCO₂ emissions

Bus San Diego to Buffalo: Trip Overview

Average Ticket PriceUS$277
Average Bus Trip Duration3d 8h
Number of daily buses10.833333333333334
Earliest bus departure7:15am
Distance3527 km
Latest bus departure7:35pm

San Diego to Buffalo Bus

Busbud helps you find a bus from San Diego to Buffalo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from San Diego to Buffalo will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Buffalo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip San Diego, CA, US - Buffalo, NY

  1. What is the travel distance from San Diego to Buffalo?

    The distance covered from San Diego to Buffalo is 3518 km (2181 miles).

  2. What are the departure and arrival locations for buses traveling from San Diego to Buffalo?

    Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Buffalo Airport, in Buffalo.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-22
No data
06-23
No data
Today
No data
06-25
US$290
06-26
No data
06-27
No data
06-28
No data
06-29
No data
busbud logoThe cheapest trip from San Diego to Buffalo was searched and found on Jun 25, 2025 with a price of US$290

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Buffalo, as early as possible.

You can expect to pay from US$290 to US$290 for a bus ticket from San Diego to Buffalo based on the last 2 days. You can expect to find the cheapest price for the trip at US$290 which is on 2025-06-25.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Buffalo!

Much more than a mere vehicle taking you from San Diego to Buffalo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Buffalo will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Buffalo.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from San Diego to Buffalo?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego by bus?

Bus from San Diego to Buffalo

You can also go to Buffalo by train

Train from San Diego to Buffalo

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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