Bus Tickets from Chicago to San Diego, CA, US

Previously seen trips

Next departures for Chicago to San Diego on September 27
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
537-517 W. Jackson Blvd
Downtown SD (Seaport)No tags
FlixBus + Greyhound
Chicago 95Th & Dan Ryan
Downtown SD (Seaport)No tags
FlixBus + Greyhound
Chicago 95Th & Dan Ryan
UCSD Health La Jolla StationNo tags
FlixBus + Greyhound
Chicago 95Th & Dan Ryan
San Diego (Old Town-FlixBus)No tags
Greyhound + FlixBus
Chicago 95Th & Dan Ryan
Greyhound Bus StopNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Chicago to San Diego

Bus
Average PriceUS$129 - US$461Average Duration2d 7h
69kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$345 - US$345Average Duration2d 17h
254kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Chicago to San Diego

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 7 hours 40 minutes, and with fares starting at just US$129, it presents an excellent value for a comfortable ride.

22bus per day
2d 7hAverage Duration
US$129Cheapest ticket
69kgCO₂ emissions

Bus Chicago to San Diego, CA, US: Trip Overview

Average Ticket PriceUS$180
Average Bus Trip Duration2d 7h
Number of daily buses22
Earliest bus departure12:15am
Distance2775 km
Latest bus departure11:50pm

Chicago to San Diego Bus

Busbud helps you find a bus from Chicago to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Chicago to San Diego will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Chicago to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Chicago - San Diego, CA, US

  1. What is the distance between Chicago and San Diego?

    The distance covered from Chicago to San Diego is 2788 km (1729 miles).

  2. What are the departure and arrival locations for buses traveling from Chicago to San Diego?

    Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at Mission Valley Sheraton, in San Diego.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-24
US$336
09-25
US$156
Today
US$146
09-27
US$169
09-28
US$195
09-29
US$123
09-30
US$148
10-01
US$195
busbud logoThe cheapest trip from Chicago to San Diego, CA, US was searched and found on Sep 29, 2025 with a price of US$123

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US, as early as possible.

You can expect to pay from US$123 to US$336 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$123 which is on 2025-09-29.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and San Diego!

Much more than a mere vehicle taking you from Chicago to San Diego, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Chicago to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from Chicago to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from San Diego, CA, US to Chicago

You can also go to San Diego, CA, US by train

Train from Chicago to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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