Find coaches from Chicago to San Diego, CA, US

Next departures

Next departures from Chicago to San Diego on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
537-517 W. Jackson Blvd
Downtown SD (Seaport)Cheapest
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
UCSD Health La Jolla StationFastest
Greyhound Lines, Inc. + FlixBus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)No tags
Greyhound Lines, Inc.
537-517 W. Jackson Blvd
Greyhound Bus StopNo tags
FlixBus + Greyhound Lines, Inc.
Downtown Greyhound Station
San Diego (Old Town-FlixBus)No tags

Last refresh of the prices: Last Monday at 6:58 AM CDT.

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Compare 2 ways to travel from Chicago to San Diego

busbud logoWe recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 2 days, 42 minutes and with fares starting at just US$186, it presents an excellent value for a comfortable ride.

3train per day
2d Average duration
2787 kmDistance
254kgCO₂ emissions
Bus
Average priceUS$125 - US$582Average duration2d 7h
69kg CO₂e
Train
Average priceUS$186 - US$1 547Average duration2d
254kg CO₂e

Bus Chicago to San Diego, CA, US: Trip Overview

Average ticket priceUS$217
Average bus trip duration2d 7h
Number of daily buses24
Earliest bus departure00:15
Distance2780 km
Latest bus departure22:30

Chicago to San Diego Bus

Busbud helps you find a bus from Chicago to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Chicago to San Diego will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Chicago to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Chicago - San Diego, CA, US

  1. How much does a bus ticket from Chicago to San Diego cost?

    The bus ticket price from Chicago to San Diego starts at US$125. The best way to find cheap bus tickets from Chicago to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Chicago to San Diego?

    The average travel time between Chicago and San Diego is around 2d 7h, although the fastest bus will take about 2d 2h. This is the time it takes to travel the 2788 km that separates the two cities.

  3. How many daily bus connections are there between Chicago and San Diego?

    The number of buses from Chicago to San Diego can differ depending on the day of the week. On average, there are 24 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Chicago to San Diego?

    When taking the bus from Chicago to San Diego, you can travel comfortably and safely with Greyhound, FlixBus.

  5. What are the departure and arrival stations when taking the bus from Chicago to San Diego?

    Buses travelling between Chicago and San Diego leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Mission Valley Sheraton, Old Town Courtyard Marriot, Downtown Holiday Inn.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$209
29/10
US$233
Today
US$297
31/10
US$265
01/11
US$248
02/11
US$248
03/11
US$185
04/11
US$132
busbud logoThe cheapest trip from Chicago to San Diego, CA, US was searched and found on 04 Nov 2025 with a price of US$132

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US as early as possible.

You can expect to pay from US$132 to US$398 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$132, which is on 2025-11-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and San Diego!

Much more than a mere vehicle taking you from Chicago to San Diego, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Chicago to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from Chicago to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from San Diego, CA, US to Chicago

You can also go to San Diego, CA, US by train

Train from Chicago to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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