Bus Tickets from Panama City, US to Chicago

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TodayAug 11
from US$170
TomorrowAug 12
WedAug 13
ThuAug 14
FriAug 15
SatAug 16
SunAug 17
MonAug 18

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 11 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 12 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 13 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 12 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 11 at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: August 13 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 7:11 AM CDT.

Prices and availability are subject to change.

Accepted payments

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Bus Panama City, US to Chicago: Trip Overview

Average Ticket PriceUS$214
Average Bus Trip Duration1d 6h
Number of daily buses7
Earliest bus departure7:40am
Distance1310 km
Latest bus departure9:10pm

Panama City to Chicago Bus

Busbud helps you find a bus from Panama City to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Panama City to Chicago.

Discover how much the bus trip from Panama City to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Panama City, US - Chicago

  1. What is the distance between Panama City and Chicago?

    The distance covered from Panama City to Chicago is 1314 km (815 miles).

  2. What are the departure and arrival locations for buses traveling from Panama City to Chicago?

    Buses traveling this route start their trip at Panama City Greyhound Bus Station, in Panama City, and end it at Downtown Greyhound Station, in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-09
US$199
08-10
No data
Today
US$162
08-12
No data
08-13
No data
08-14
No data
08-15
No data
08-16
No data
busbud logoThe cheapest trip from Panama City, US to Chicago was searched and found on Aug 11, 2025 with a price of US$162

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Chicago, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Chicago!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Panama City to Chicago.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Panama City to Chicago will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Panama City to Chicago.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Panama City, US by bus?

Bus from Panama City, US to Chicago

Why choose Busbud?

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