Bus Tickets from Lyon to Brussels

Next departures

Next departures for Lyon to Brussels on September 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Flixbus
Perrache
MidiCheapest
BlaBlaCar Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)Fastest
BlaBlaCar Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)No tags
Flixbus
Aéroport LYS
Brussels North Train StationNo tags
BlaBlaCar Bus
Lyon - Perrache Bus Station
Brussels-South (Gare du Midi)No tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 3 ways to go from Lyon to Brussels

Bus
Average PriceUS$22 - US$182Average Duration11h 55m
14kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$69 - US$262Average Duration4h 13m
14kg CO₂e5 out of 5 stars
Fastest
Carpool
Average PriceUS$39 - US$108Average Duration7h 40m
24kg CO₂e4 out of 5 stars
busbud logoBusbud recommends taking the train from Lyon to Brussels

Among the sustainable travel choices, the train stands out as a good way to reach Brussels. The journey takes about 4 hours 13 minutes, and with fares starting at just US$69, it presents an excellent value for a comfortable ride.

19train per day
4h 13mAverage Duration
US$69Cheapest ticket
14kgCO₂ emissions

Bus Lyon to Brussels: Trip Overview

Average Ticket PriceUS$51
Average Bus Trip Duration11h 55m
Number of daily buses23
Earliest bus departure12:15am
Distance573 km
Latest bus departure11:59pm

Lyon to Brussels Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Lyon to Brussels.

We make sure you can find a bus service from Lyon to Brussels from the most reliable bus companies operating this trip.

Discover how much the bus trip from Lyon to Brussels will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Lyon - Brussels

  1. How far is Lyon from Brussels?

    The distance covered from Lyon to Brussels is 569 km (353 miles).

  2. What are the departure and arrival locations for buses traveling from Lyon to Brussels?

    Buses traveling this route start their trip at Perrache, in Lyon, and end it at Brussels South (Gare du Midi), in Brussels.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-11
US$44
09-12
US$57
Today
US$44
09-14
US$32
09-15
US$26
09-16
US$22
09-17
US$23
09-18
US$19
busbud logoThe cheapest trip from Lyon to Brussels was searched and found on Sep 18, 2025 with a price of US$19

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Brussels, as early as possible.

You can expect to pay from US$19 to US$133 for a bus ticket from Lyon to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at US$19 which is on 2025-09-18.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Lyon to Brussels but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Lyon to Brussels, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Lyon to Brussels will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Lyon to Brussels.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Lyon to Brussels?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Lyon by bus?

Bus from Brussels to Lyon

You can also go to Brussels by train

Train from Lyon to Brussels

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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