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- This trip is recommended because it is the: Cheapest + Fastest
Last refresh of the prices: Last Monday at 6:27 AM EDT.
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Compare 2 ways to go from Greenville to Pittsburgh
Busbud recommends taking the bus from Greenville to PittsburghAmong the sustainable travel choices, the bus stands out as a good way to reach Pittsburgh. The journey takes about 16 hours 20 minutes, and with fares starting at just US$82, it presents an excellent value for a comfortable ride.
Bus Greenville, SC to Pittsburgh: Trip Overview
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Greenville to Pittsburgh Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Pittsburgh.
We make sure you can find a bus service from Greenville to Pittsburgh from the most reliable bus companies operating this trip.
Discover how much the bus trip from Greenville to Pittsburgh will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Greenville and Pittsburgh?
Frequently asked questions on the trip Greenville, SC - Pittsburgh
What is the distance between Greenville and Pittsburgh?
The distance between Greenville and Pittsburgh is approximately 657 km (408 miles).
What are the departure and arrival locations for buses traveling from Greenville to Pittsburgh?
Buses departing from Guadalajara Supermarket Bus Stop in Greenville will take you to Intermodal Station in Pittsburgh.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Pittsburgh was searched and found on Aug 12, 2025 with a price of US$119To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Pittsburgh, as early as possible.
You can expect to pay from US$119 to US$125 for a bus ticket from Greenville, SC to Pittsburgh based on the last 2 days. You can expect to find the cheapest price for the trip at US$119 which is on 2025-08-12.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Pittsburgh but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Greenville to Pittsburgh, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Pittsburgh will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Pittsburgh.
Did you know?
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
What's the cheapest way to go from Greenville, SC to Pittsburgh?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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