Bus Tickets from Chicago to Jefferson City, MO

Next departures

Next departures for Chicago to Jefferson City on October 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Downtown Greyhound Station
Jefferson CityCheapest
FlixBus + Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Jefferson CityFastest
Greyhound Lines, Inc.
Downtown Greyhound Station
Jefferson CityNo tags
Greyhound Lines, Inc.
537-517 W. Jackson Blvd
Jefferson CityNo tags
Greyhound Lines, Inc.
Chicago 95Th & Dan Ryan
Jefferson CityNo tags

Last refresh of the prices: Yesterday at 10:55 PM CDT.

Accepted payments

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Compare 2 ways to go from Chicago to Jefferson City

Bus
Average PriceUS$42 - US$143Average Duration16h 30m
13kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$49 - US$192Average Duration7h 46m
48kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Chicago to Jefferson City

Among the sustainable travel choices, the train stands out as a good way to reach Jefferson City. The journey takes about 7 hours 46 minutes, and with fares starting at just US$49, it presents an excellent value for a comfortable ride.

2train per day
7h 46mAverage Duration
US$49Cheapest ticket
48kgCO₂ emissions

Bus Chicago to Jefferson City, MO: Trip Overview

Average Ticket PriceUS$63
Average Bus Trip Duration16h 30m
Number of daily buses6
Earliest bus departure12:15am
Distance532 km
Latest bus departure10:30pm

Chicago to Jefferson City Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Jefferson City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Jefferson City.

Discover how much the bus trip from Chicago to Jefferson City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Jefferson City, MO

  1. What is the travel distance from Chicago to Jefferson City?

    The distance between Chicago and Jefferson City is approximately 531 km (329 miles).

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-29
US$74
09-30
US$64
Today
US$72
10-02
US$62
10-03
US$67
10-04
US$69
10-05
US$57
10-06
US$58
busbud logoThe cheapest trip from Chicago to Jefferson City, MO was searched and found on Oct 5, 2025 with a price of US$57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Jefferson City, MO, as early as possible.

You can expect to pay from US$57 to US$86 for a bus ticket from Chicago to Jefferson City, MO based on the last 2 days. You can expect to find the cheapest price for the trip at US$57 which is on 2025-10-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Jefferson City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Jefferson City.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Jefferson City will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Jefferson City.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Chicago by bus?

Bus from Jefferson City, MO to Chicago

You can also go to Jefferson City, MO by train

Train from Chicago to Jefferson City, MO

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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